Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 376 to 400 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1084 increased apoptosis regulator BAX (PR:000002193) 2124: increased, Bax expression
1032 increased aromatase (PR:000006100) None
1083 increased aromatase activity (GO:0070330) aromatase (PR:000006100) 2293: Aromatase, induction
507 decreased signaling (GO:0023052) aromatase (PR:000006100) 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
777 decreased mRNA transcription (GO:0009299) aromatase (PR:000006100) 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
32 decreased aromatase activity (GO:0070330) aromatase (PR:000006100)
423 decreased aromatase activity (GO:0070330) aromatase isoform 1 (PR:000038849) 800: Decreased, Aromatase (Cyp19a1) mRNA
468 increased Arrhythmias, Cardiac (MESH:D001145) 1106: Occurrence, cardiac arrhythmia
101 increased aryl hydrocarbon receptor activity (GO:0004874) aryl hydrocarbon receptor (PR:000003858) 18: Activation, AhR
102 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) None
205 increased signaling (GO:0023052) aryl hydrocarbon receptor (PR:000003858) 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes
1073 increased aryl hydrocarbon receptor binding (GO:0017162) aryl hydrocarbon receptor (PR:000003858) 18: Activation, AhR
499 increased protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) 944: dimerization, AHR/ARNT
500 increased protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) 944: dimerization, AHR/ARNT
502 decreased protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) 945: reduced dimerization, ARNT/HIF1-alpha
103 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) None
9 pathological brain inflammation (MP:0001847) astrocyte (CL:0000127) 188: Neuroinflammation
921 increased kinase activity (GO:0016301) astrocyte (CL:0000127) 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
119 decreased ATP biosynthetic process (GO:0006754) ATP (CHEBI:15422)
363 decreased ion channel activity (GO:0005216) ATP-sensitive inward rectifier potassium channel 1 (PR:000001978) 697: impaired, ion channels
77 increased atrioventricular block (MESH:D054537) 444: Increased, Atrioventricular block and bradycardia
1039 increased cell activation involved in immune response (GO:0002263) B cell (CL:0000236) None
1058 occurrence B cell activation involved in immune response (GO:0002312) B cell (CL:0000236) 2256: Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation
1037 increased gene conversion of immunoglobulin genes (GO:0002206) B cell receptor complex (GO:0019815) None
1053 occurrence gene conversion of immunoglobulin genes (GO:0002206) B cell receptor complex (GO:0019815) 2254: Gluten-reactive and transglutaminase 2 reactive B cell receptors, generation