Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 376 to 400 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1074 occurrence cornification (GO:0070268) epithelium of vagina (UBERON:0001344) 2306: Persistent vaginal cornification
1075 increased serotonin receptor activity (GO:0099589) Surface of brain (FMA:86594) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1076 increased increased serotonin level (MP:0010069) extracellular region (GO:0005576) 1320: Increased, extracellular serotonin
1077 increased increased serotonin level (MP:0010069) serotonin (CHEBI:28790) 1320: Increased, extracellular serotonin
1079 abnormal embryonic organ development (GO:0048568) penis (UBERON:0000989) 2082: Hypospadias, increased
1080 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 1A (PR:000001161) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1134 delayed delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1117 decreased Decreased circulating gonadotropin level (HP:0030339) circulatory system (UBERON:0001009) 1986: Decreased, Gonadotropins
1118 increased prolonged estrous cycle (MP:0009006) 1075: prolonged, estrus cycle
1119 increased prolonged estrus (MP:0009017) 1075: prolonged, estrus cycle
1120 decreased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 968: Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons
1121 increased hormone secretion (GO:0046879) gonadotropin releasing neuron (CL:0011111) 2137: Increase, Gonadotropins concentration in plasma
1122 increased hormone secretion (GO:0046879) Gonadotropin Releasing Hormone (MESH:D007987) 1047: Increased, secretion of GnRH from hypothalamus
1124 increased regulation of vascular permeability (GO:0043114) 2384: Decrease, Vascular integrity
1126 decreased protein import into nucleus, translocation (GO:0000060) androgen receptor (PR:000004191) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1127 decreased regulation of DNA binding (GO:0051101) androgen (CHEBI:50113) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1128 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor receptor 2 (PR:000001449) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1129 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1130 decreased fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1132 decreased cell activation (GO:0001775) fibroblast growth factor 2 (PR:000007489) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1133 disrupted external genitalia morphogenesis (GO:0035261) prepuce (UBERON:0011374) 2400: Preputial epithelial morphogenesis, disrupted
1146 increased Hepatic bridging fibrosis (HP:0012852) 2414: COL3A1 Signaling Pathway
1147 increased protein oxidation (GO:0018158) 1767: Increase, Protein oxidation
1148 occurrence Amyotrophic lateral sclerosis (HP:0007354) adult central nervous system (UBERON:6003623) 2416: human amyotrophic lateral sclerosis (ALS)
1145 increased female gonad development (GO:0008585) immature gonad (UBERON:2005272) 2417: Increased, differentiation to ovaries