Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 401 to 425 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1129 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1128 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor receptor 2 (PR:000001449) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1127 decreased regulation of DNA binding (GO:0051101) androgen (CHEBI:50113) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1126 decreased protein import into nucleus, translocation (GO:0000060) androgen receptor (PR:000004191) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1124 increased regulation of vascular permeability (GO:0043114) 2384: Decrease, Vascular integrity
1122 increased hormone secretion (GO:0046879) Gonadotropin Releasing Hormone (MESH:D007987) 1047: Increased, secretion of GnRH from hypothalamus
1121 increased hormone secretion (GO:0046879) gonadotropin releasing neuron (CL:0011111) 2137: Increase, Gonadotropins concentration in plasma
1120 decreased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 968: Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons
1119 increased prolonged estrus (MP:0009017) 1075: prolonged, estrus cycle
1118 increased prolonged estrous cycle (MP:0009006) 1075: prolonged, estrus cycle
1117 decreased Decreased circulating gonadotropin level (HP:0030339) circulatory system (UBERON:0001009) 1986: Decreased, Gonadotropins
1088 decreased decreased neurotransmitter release (MP:0003990) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
1097 decreased Dementia (HP:0000726) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1096 increased palatal shelves fail to meet at midline (MP:0009888) secondary palate (UBERON:0001716) 2041: Decrease, facial prominence outgrowth
1095 increased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) 2041: Decrease, facial prominence outgrowth
1094 decreased ovarian follicle development (GO:0001541) granulosa cell (CL:0000501) 1800: Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
1091 increased cell death (GO:0008219) cell (GO:0005623) 1825: Increase, Cell death
1090 decreased response to odorant (GO:1990834) Nose (FMA:46472) 2317: Loss of olfactory function
1089 increased Pulmonary edema (HP:0100598) lung (UBERON:0002048) 2316: Increased, pulmonary edema
1085 increased wounding (MP:0013027) Nose (FMA:46472) 2312: Increased, nasal lesions
1082 increased estradiol secretion (GO:0035938) Glandular part of endometrium (FMA:86488) 2251: Estradiol availability, increased
1083 increased aromatase activity (GO:0070330) aromatase (PR:000006100) 2293: Aromatase, induction
1084 increased apoptosis regulator BAX (PR:000002193) 2124: increased, Bax expression
1098 decreased long term synaptic depression (GO:0060292) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1086 decreased cytochrome-c oxidase activity (GO:0004129) mitochondrion (GO:0005739) 1840: Inhibition, cytochrome oxidase