Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 401 to 425 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
4 decreased mitochondrial electron transport, NADH to ubiquinone (GO:0006120) NADH-ubiquinone oxidoreductase chain 1 (PR:000031316) 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
448 increased Microvesicular hepatic steatosis (HP:0001414) 838: Induction, Microvesicular fat
373 increased microtubule depolymerization (GO:0007019) microtubule (GO:0005874) 720: Disruption, Microtubule dynamics
779 decreased microphthalmia (MP:0001297) eye (UBERON:0000970) 1878: Decreased, Eye size
202 increased MHC protein complex assembly (GO:0002396) 398: Activation, Dendritic Cells
476 occurrence Metaplasia (MESH:D008679) goblet cell (CL:0000160) 920: Occurrence, Metaplasia of goblet cells
1107 increased Metaplasia (MESH:D008679) Squamous cell (FMA:66769)
1109 increased Metaplasia (MESH:D008679) endometrium epithelium (UBERON:0004811) 1068: Endometrial squamous metaplasia, Increase
574 increased metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
742 delayed metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
157 increased metabolic process (GO:0008152) thiamethoxam (CHEBI:39185) 77: Production, Critical Metabolites (CGA 330050 and CGA 265307)
158 increased metabolic process (GO:0008152) metabolite (CHEBI:25212) 77: Production, Critical Metabolites (CGA 330050 and CGA 265307)
225 increased metabolic process (GO:0008152) 409: Metabolism of AFB1, Production of Reactive Electrophiles
506 increased metabolic process (GO:0008152) thyroxine (CHEBI:30660) 961: Increased, Clearance of thyroxine from serum
1128 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor receptor 2 (PR:000001449) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1129 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
533 increased mesenchymal cell proliferation (GO:0010463) mesenchymal cell (CL:0008019) 1033: Increased, proliferation of mesenchymal cells
64 decreased memory (GO:0007613) 341: Impairment, Learning and memory
400 increased membrane hyperpolarization (GO:0060081) 763: hyperpolarisation, neuron
875 occurrence membrane fusion (GO:0061025) host cell membrane (GO:0033644) None
876 occurrence membrane fusion (GO:0061025) transmembrane protease serine 2 (PR:000016456) 1738: SARS-CoV-2 cell entry
932 occurrence membrane fusion (GO:0061025) vesicle membrane (GO:0012506) 2159: Influenza A virus (IAV) cell entry
947 occurrence membrane fusion (GO:0061025) influenzavirus hemagglutinin (PR:000049750) None
333 increased membrane depolarization (GO:0051899) 599: prolonged, Depolarization of neuronal membrane
50 occurrence membrane depolarization (GO:0051899) 616: Occurrence, A paroxysmal depolarizing shift