Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 426 to 450 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
455 decreased catalytic activity (GO:0003824) uroporphyrinogen decarboxylase (PR:000017134) 845: Inhibition, UROD
458 decreased regulation of intracellular pH (GO:0051453) 867: Decrease, Intracellular pH
464 decreased signaling (GO:0023052) solute carrier family 22 member 6 (PR:000014993) 877: Inhibition, organic anion transporter 1 (OAT1)
474 decreased epithelial cell apoptotic process (GO:1904019) None
481 decreased respiratory function trait (VT:0002327) 1250: Decrease, Lung function
483 decreased biosynthetic process (GO:0009058) 5,6,7,8-tetrahydrobiopterin (CHEBI:15372) 934: KE3 : Decrease, Tetrahydrobiopterin
484 decreased proteasome complex disassembly (GO:1903009) GTP cyclohydrolase 1 (PR:000007893) 935: KE2 : Decrease, GTPCH-1
485 decreased catalytic activity (GO:0003824) nitric oxide synthase, endothelial (PR:000011328) 973: KE5 : Decrease, AKT/eNOS activity
486 decreased catalytic activity (GO:0003824) AKT kinase (PR:000029189) 973: KE5 : Decrease, AKT/eNOS activity
487 decreased nitric oxide biosynthetic process (GO:0006809) nitric oxide (CHEBI:16480) 933: KE6 : Depletion, Nitric Oxide
498 decreased gene expression (GO:0010467) vascular endothelial growth factor A (PR:000017284) 948: reduced production, VEGF
501 decreased protein dimerization activity (GO:0046983) hypoxia-inducible factor 1-alpha (PR:000008555) 945: reduced dimerization, ARNT/HIF1-alpha
502 decreased protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) 945: reduced dimerization, ARNT/HIF1-alpha
507 decreased signaling (GO:0023052) aromatase (PR:000006100) 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
508 decreased estrogen (CHEBI:50114) None
509 decreased neurotransmitter secretion (GO:0007269) metastasis-suppressor KiSS-1 (rat) (PR:Q7TSB7) None
510 decreased luteinizing hormone secretion (GO:0032275) Luteinizing hormone (CHEBI:81568)
295 delayed abnormal ovulation (MP:0001928) 532: Delayed, Ovulation
560 delayed estrus (GO:0060209) None
742 delayed metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
1134 delayed delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
36 disrupted ovulation cycle (GO:0042698) None
85 disrupted protein domain specific binding (GO:0019904) 158: N/A, Interferences with SH-/selen-proteins
102 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) None
103 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) None