Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 426 to 450 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
899 occurrence Blood vessel (FMA:63183) None
900 occurrence blood vessel remodeling (GO:0001974) blood vessel (UBERON:0001981) 2069: Occurrence, Abnormal Vascular Remodeling
924 functional change blood vessel endothelial cell (CL:0000071) 2096: Occurrence, (Micro)vascular dysfunction
1140 increased increased uterus weight (MP:0004904) body of uterus (UBERON:0009853) 2413: Increased, uterine weight
1006 increased cell death (GO:0008219) bone cell (CL:0001035) 1825: Increase, Cell death
738 occurrence secondary generalized seizure (NBO:0000703) brain (UBERON:0000955) 1788: Status epilepticus
55 decreased gene expression (GO:0010467) brain-derived neurotrophic factor (PR:000004716)
56 decreased secretion (GO:0046903) brain-derived neurotrophic factor (PR:000004716) 381: Reduced levels of BDNF
959 increased Breast carcinoma (HP:0003002) BRCA1-A complex (GO:0070531) 1971: Increased, tumor growth
644 pathological Breast Neoplasms (MESH:D001943) 1193: N/A, Breast Cancer
381 increased cell death (GO:0008219) bronchial epithelial cell (CL:0002328) 733: Increase, Necrosis (terminal bronchiolar cells)
382 increased epithelial cell proliferation (GO:0050673) bronchial epithelial cell (CL:0002328) 734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
383 increased hyperplasia (MESH:D006965) bronchial epithelial cell (CL:0002328) 735: Increase, Hyperplasia (terminal bronchiolar cells)
837 increased Elevated C-reactive protein level (HP:0011227) C-reactive protein (PR:000005897) 1868: Hyperinflammation
688 increased neuropeptide hormone activity (GO:0005184) Calcitonin gene-related peptide 1 (CHEBI:80337) 1433: Increased CGRP, neuronal release of CGRP
615 increased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
304 abnormal binding (GO:0005488) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
321 abnormal calmodulin binding (GO:0005516) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
54 decreased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
117 increased calcium ion (CHEBI:39124) 50: Increase, Ca++ (intracellular)
116 decreased calcium-transporting ATPase activity (GO:0005388) calcium ion-transporting ATPase complex (GO:0090534) 51: Inhibition, Ca++ ATPase
922 increased calcium amount (VT:0010499) calcium(2+) (CHEBI:29108) 1339: Increase, intracellular calcium
419 increased cystolithiasis (MP:0011625) Calculi (MESH:D002137) 793: Increase, Urinary bladder calculi
305 abnormal signaling (GO:0023052) calmodulin (PR:000004978) 1243: Altered, Ca2+-calmodulin activated signal transduction
222 abnormal capillary plexus (UBERON:0035753) 298: Insufficiency, Vascular