Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 426 to 450 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1062 disrupted meiosis I (GO:0007127) oocyte (CL:0000023) 1882: Disrupted, initiation of meiosis of oogonia in the ovary
351 decreased mating pheromone secretion (GO:0071834) pheromone (CHEBI:26013) 678: Reduced, Pheromone release
563 increased mammary gland hyperplasia (MP:0000630) 1078: Hyperplasia, Mammary gland
447 occurrence Mallory bodies (MP:0014045) 839: Formation, Mallory body
871 increased Malignant mesothelioma (HP:0100001) mesothelioma (MESH:D008654) 1090: Increased, mesotheliomas
741 increased male sex differentiation (GO:0046661) population of organisms (PCO:0000001) 1791: Increased, Male Biased Sex Ratio
740 increased male gonad development (GO:0008584) immature gonad (UBERON:2005272) 1790: Increased, Differentiation to Testis
715 increased macrophage activation involved in immune response (GO:0002281) macrophage (CL:0000235) 1394: Induction, persistent proliferation/sustained proliferation
649 decreased macrophage activation (GO:0042116) 1198: Activation, Macrophages
191 increased macrophage activation (GO:0042116) Kupffer cell (CL:0000091) 134: Increase, Kupffer cell activation
858 increased macrophage activation (GO:0042116) macrophage (CL:0000235) 1497: Increased, recruitment of inflammatory cells
838 decreased Lymphopenia (HP:0001888) lymphocyte (CL:0000542) 1868: Hyperinflammation
840 increased luteinizing hormone signaling pathway (GO:0042700) None
510 decreased luteinizing hormone secretion (GO:0032275) Luteinizing hormone (CHEBI:81568)
10 increased loss of dopaminergic neurons (MP:0003244) 890: Degeneration of dopaminergic neurons of the nigrostriatal pathway
122 decreased long-term synaptic potentiation (GO:0060291) 166: Decreased, Long-term potentiation (LTP)
1098 decreased long term synaptic depression (GO:0060292) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
334 increased locomotion (GO:0040011) 622: Increased, locomotion
344 decreased locomotion (GO:0040011) 635: Decreased, locomotion
152 increased liver vascular congestion (MP:0010019) 246: Increase, RBC congestion in liver
471 occurrence liver inflammation (MP:0001860) 902: Inflammation, Liver
192 occurrence liver fibrosis (MP:0003333) liver (UBERON:0002107)
281 decreased lipoprotein transport (GO:0042953) lipoprotein (CHEBI:6495) 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins
977 disrupted lipid storage (GO:0019915) 2225: Disrupted Lipid Storage
962 increased lipid oxidation (GO:0034440) polyunsaturated fatty acid (CHEBI:26208) 1445: Increase, Lipid peroxidation