Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 451 to 475 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
305 abnormal signaling (GO:0023052) calmodulin (PR:000004978) 1243: Altered, Ca2+-calmodulin activated signal transduction
222 abnormal capillary plexus (UBERON:0035753) 298: Insufficiency, Vascular
171 increased signaling (GO:0023052) carbohydrate-responsive element-binding protein (PR:000010460) 66: Activation, ChREBP
367 increased Carcinoma (MESH:D002277)
19 decreased peptide secretion (GO:0002790) cardioactive peptide (fruit fly) (PR:Q9VCW0) 1266: Decrease, Circulating crustacean cardioactive peptide
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
495 abnormal cardiovascular system development (GO:0072358) cardiovascular system (UBERON:0004535) 317: Altered, Cardiovascular development/function
251 decreased gene expression (GO:0010467) carnitine O-palmitoyltransferase 1, liver isoform (PR:000005835) 472: Down Regulation, CPT1A
877 occurrence endocytosis involved in viral entry into host cell (GO:0075509) cathepsin L1 (human) (PR:P07711) 1738: SARS-CoV-2 cell entry
752 decreased cell proliferation (GO:0008283) cell (GO:0005623) 1821: Decrease, Cell proliferation
1091 increased cell death (GO:0008219) cell (GO:0005623) 1825: Increase, Cell death
1106 abnormal cell differentiation (GO:0030154) cell (GO:0005623) 1560: Cell differentiation, altered
701 disrupted regulation of cell cycle (GO:0051726) cell cycle-related cyclin (PR:000029191) 1505: Increase, Cell cycle disruption
226 increased mutation (MESH:D009154) cellular tumor antigen p53 (PR:000003035) 376: Increased, Induced Mutations in Critical Genes
772 occurrence epithelial to mesenchymal transition (GO:0001837) cellular_component (GO:0005575) None
809 decreased cftr isoform 1 (PR:000001045) None
854 increased chemokine secretion (GO:0090195) Chemokine (FMA:241981) 1496: Increased, secretion of proinflammatory mediators
195 increased chemokine activity (GO:0008009) Chemokine (FMA:241981) 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
14 increased chitin biosynthetic process (GO:0006031) chitin (CHEBI:17029) 990: Increase, Incomplete ecdysis
49 decreased GABA-gated chloride ion channel activity (GO:0022851) chloride (CHEBI:17996)
399 increased chloride transmembrane transport (GO:1902476) chloride (CHEBI:17996) 761: Increased, Chloride conductance
551 increased cholecystokinin (PR:000005110) 1061: prolonged, elevation of serun CCK
129 occurrence cholestasis (MESH:D002779)
92 decreased mitochondrial transport (GO:0006839) cholesterol (CHEBI:16113) 447: Reduction, Cholesterol transport in mitochondria
280 decreased cholesterol biosynthetic process (GO:0006695) cholesterol (CHEBI:16113)