Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 451 to 475 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
905 increased endocrine signaling (GO:0038002) estrone (CHEBI:17263) 2092: Promotion, Ovarian Cancer
709 increased endocytosis (GO:0006897) lysosomal membrane (GO:0005765) 1539: Endocytotic lysosomal uptake
767 increased endocytosis involved in viral entry into host cell (GO:0075509) None
873 occurrence endocytosis involved in viral entry into host cell (GO:0075509) host cell membrane (GO:0033644) None
877 occurrence endocytosis involved in viral entry into host cell (GO:0075509) cathepsin L1 (human) (PR:P07711) 1738: SARS-CoV-2 cell entry
1108 increased Endometrial carcinoma (HP:0012114) adenosquamous carcinoma (MESH:D018196) 1070: Increased, adenosquamous carcinomas of endometrium
396 increased endometrium hyperplasia (MP:0009092) glandular cell of endometrium (CL:0002656) 772: Increase, Hyperplasia (glandular epithelial cells of endometrium)
1009 increased endothelial cell apoptotic process (GO:0072577) 2068: Increase, Endothelial Dysfunction
642 increased endothelial cell migration (GO:0043542) 1190: Increased, Migration (Endothelial Cells)
641 increased endothelial cell proliferation (GO:0001935) 1189: Increased, Proliferation (Endothelial cells)
220 abnormal endothelium development (GO:0003158) 110: Impairment, Endothelial network
993 increased energy deposition event (RBO:00015021) 1686: Deposition of Energy
698 decreased enzyme inhibitor activity (GO:0004857) histone deacetylase 1 (PR:000008478) 1502: Histone deacetylase inhibition
473 occurrence epidermal growth factor-activated receptor activity (GO:0005006) epidermal growth factor receptor (PR:000006933) 941: Activation, EGFR
474 decreased epithelial cell apoptotic process (GO:1904019) None
365 increased epithelial cell proliferation (GO:0050673) nephron tubule epithelial cell (CL:1000494) None
382 increased epithelial cell proliferation (GO:0050673) bronchial epithelial cell (CL:0002328) 734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
690 increased epithelial cell proliferation (GO:0050673) kidney tubule cell (CL:1000507) 710: Increase, Regenerative cell proliferation (tubular epithelial cells)
792 decreased epithelial cilium movement (GO:0003351) None
772 occurrence epithelial to mesenchymal transition (GO:0001837) cellular_component (GO:0005575) None
974 occurrence epithelial to mesenchymal transition (GO:0001837) Epithelial cell (FMA:66768) 1457: Epithelial Mesenchymal Transition
1082 increased estradiol secretion (GO:0035938) Glandular part of endometrium (FMA:86488) 2251: Estradiol availability, increased
34 decreased estrogen biosynthetic process (GO:0006703) 17beta-estradiol (CHEBI:16469)
137 increased estrogen receptor activity (GO:0030284) estrogen receptor (PR:000007204)
144 decreased estrogen receptor activity (GO:0030284) estrogen receptor (PR:000007204)