Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 451 to 475 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
550 abnormal lipid metabolic process (GO:0006629) 1060: Alteration, lipid metabolism
328 decreased life span trait (VT:0005372)
390 increased Leydig cell hyperplasia (MP:0001152) Leydig cell (CL:0000178) 744: Increase, Hyperplasia (Leydig cells)
459 increased leukocyte mediated cytotoxicity (GO:0001909) 768: Increase, Cytotoxicity
215 decreased learning or memory (GO:0007611) 402: Cognitive function, decreased
59 decreased learning (GO:0007612) 341: Impairment, Learning and memory
142 abnormal larval development (GO:0002164)
836 increased lactate dehydrogenase activity (GO:0004457) 1868: Hyperinflammation
921 increased kinase activity (GO:0016301) astrocyte (CL:0000127) 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
437 decreased kidney plasma flow trait (VT:0005524) 820: Decreased, Renal plasma flow
165 increased kidney failure (MP:0003606) 759: Increased, Kidney Failure
412 increased kidney epithelium hyperplasia (MP:0004968) nephron tubule epithelial cell (CL:1000494) 784: Increase, Hyperplasia (tubular epithelial cells)
140 increased Kidney Diseases (MESH:D007674) 252: Increase, Renal pathology due to VTG deposition
27 decreased ketosis (MESH:D007662)
199 increased keratinocyte activation (GO:0032980) 826: Activation, Keratinocytes
576 occurrence ischemia (MESH:D007511) kidney (UBERON:0002113) 1105: Occurrence, renal ischemia
229 increased ionotropic glutamate receptor activity (GO:0004970) ionotropic glutamate receptor complex (GO:0008328) 875: Binding of agonist, Ionotropic glutamate receptors
362 decreased ion channel activity (GO:0005216) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 697: impaired, ion channels
363 decreased ion channel activity (GO:0005216) ATP-sensitive inward rectifier potassium channel 1 (PR:000001978) 697: impaired, ion channels
236 decreased iodide transport (GO:0015705) iodide (CHEBI:16382)
213 decreased iodide peroxidase activity (GO:0004447) thyroid peroxidase (PR:000016584) 279: Thyroperoxidase, Inhibition
553 increased intracellular estrogen receptor signaling pathway (GO:0030520) estrogen receptor alpha complex (PR:000027727) 1065: Activation, estrogen receptor alpha
282 decreased intracellular cholesterol transport (GO:0032367) cholesterol (CHEBI:16113) 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
831 increased interleukin-6 production (GO:0032635) interleukin-6 (PR:000001393) 1868: Hyperinflammation
519 decreased interleukin-4 production (GO:0032633) interleukin-4 (PR:000001391)