Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 476 to 500 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
282 decreased intracellular cholesterol transport (GO:0032367) cholesterol (CHEBI:16113) 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
429 decreased cholesterol (CHEBI:16113) None
734 decreased cholesterol transport (GO:0030301) cholesterol (CHEBI:16113) 807: Decreased, cholesterol
679 abnormal cholesterol (CHEBI:16113) 1289: Perturbation of cholesterol
735 decreased cholesterol transport (GO:0030301) cholesteryl ester (CHEBI:17002) 807: Decreased, cholesterol
862 increased chromosome breakage (GO:0031052) chromosome (GO:0005694)
863 increased chromosomal instability (MP:0008866) chromosome (GO:0005694)
371 abnormal chromosome movement towards spindle pole (GO:0051305) chromosome (GO:0005694) 752: Altered, Meiotic chromosome dynamics
1011 increased chromosome (GO:0005694) None
475 occurrence transdifferentiation (GO:0060290) ciliated epithelial cell (CL:0000067) 919: Occurrence, Transdifferentiation of ciliated epithelial cells
820 decreased apoptotic process (GO:0006915) ciliated epithelial cell (CL:0000067) 914: Decrease, Apoptosis of ciliated epithelial cells
1117 decreased Decreased circulating gonadotropin level (HP:0030339) circulatory system (UBERON:0001009) 1986: Decreased, Gonadotropins
384 increased cell death (GO:0008219) Clara cell (CL:0000158) 770: Increase, Cytotoxicity (club cells)
929 occurrence receptor-mediated endocytosis (GO:0006898) clathrin-coated vesicle membrane (GO:0030665) None
930 occurrence protein localization to endosome (GO:0036010) clathrin-coated vesicle membrane (GO:0030665) 2159: Influenza A virus (IAV) cell entry
1088 decreased decreased neurotransmitter release (MP:0003990) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
1104 increased increased synaptic depression (MP:0002916) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
584 decreased carboxylation reaction (MI:1139) coagulation factor IX (mouse) (PR:P16294) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
583 decreased carboxylation reaction (MI:1139) coagulation factor VII (mouse) (PR:P70375) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
585 decreased carboxylation reaction (MI:1139) coagulation factor X (mouse) (PR:O88947) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
188 increased collagen biosynthetic process (GO:0032964) collagen (CHEBI:3815) 68: Increase, Collagen accumulation
401 increased cell death (GO:0008219) corneal epithelial cell (CL:0000575) 776: Increase, Cytotoxicity (corneal cells)
402 increased inflammatory response (GO:0006954) corneal epithelial cell (CL:0000575) 777: Increase, Inflammation (corneal cells)
403 increased cell proliferation (GO:0008283) corneal epithelial cell (CL:0000575) 778: Increase, Regenerative cell proliferation (corneal cells)
296 decreased secretion (GO:0046903) cortical granule (GO:0060473) 533: Decreased, Cortical granule release/distribution upon fertilization