Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 501 to 525 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
271 increased corticosterone (CHEBI:16827) 653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone
619 increased cough (MESH:D003371)
272 increased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405) 655: Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
275 decreased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405)
440 increased creatinine (CHEBI:16737) 813: Increased, Serum creatinine
749 decreased cuticle development (GO:0042335) cuticle (UBERON:0001002) 1523: Decrease, Cuticular chitin content
156 occurrence Cyanosis (MESH:D003490) 321: N/A, Cyanosis occurs
700 increased positive regulation of gene expression (GO:0010628) cyclin-dependent kinase inhibitor (PR:000000014) 1504: p21 (CDKN1A) expression, increase
493 increased protein glutathionylation (GO:0010731) cysteine residue (CHEBI:32460) 927: KE1 : S-Glutathionylation, eNOS
243 increased gene expression (GO:0010467) cytochrome P450 1A1 (PR:000006101) 80: Up Regulation, CYP1A1
453 increased gene expression (GO:0010467) cytochrome P450 1A2 (PR:000006102) 850: Induction, CYP1A2/CYP1A5
454 increased gene expression (GO:0010467) cytochrome P450 1A5 (chicken) (PR:P79761) 850: Induction, CYP1A2/CYP1A5
691 increased acute inflammatory response (GO:0002526) Cytokine (FMA:84050) None
127 increased cytokine secretion (GO:0050663) Cytokine (FMA:84050) 87: Release, Cytokine
196 increased cytokine activity (GO:0005125) Cytokine (FMA:84050) 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
852 increased Cytokine (FMA:84050) None
853 increased cytokine production involved in inflammatory response (GO:0002534) Cytokine (FMA:84050) 1496: Increased, secretion of proinflammatory mediators
318 decreased glucose oxidase activity (GO:0046562) D-glucono-1,5-lactone (CHEBI:16217) 578: Decreased, Glucose oxidase enzyme activity
78 increased decreased heart rate (MESH:D001919) 444: Increased, Atrioventricular block and bradycardia
60 abnormal dendrite morphogenesis (GO:0048813) dendrite (GO:0030425) 382: Aberrant, Dendritic morphology
981 morphological change abnormal excitatory postsynaptic current amplitude (MP:0011267) dendritic spine membrane (GO:0032591) 388: Overactivation, NMDARs
994 increased DNA Strand Break (NCI:C25830) Deoxyribonucleic acid (FMA:74412) 1635: Increase, DNA strand breaks
1000 abnormal DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 155: Inadequate DNA repair
774 increased deoxyribonucleic acid (CHEBI:16991) 1879: Bulky DNA adducts, increase
634 increased oxidation-reduction process (GO:0055114) deoxyribonucleic acid (CHEBI:16991) 1238: Activation of oxidative stress pathway