Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 526 to 550 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
639 increased estrogen receptor binding (GO:0030331) deoxyribonucleic acid (CHEBI:16991) 1187: Increased, ER binding to DNA (classical pathway)
645 functional change deoxyribonucleic acid (CHEBI:16991) 1194: Increase, DNA damage
670 increased DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 1281: Increased, DNA Damage-Repair
72 increased DNA alkylation (GO:0006305) deoxyribonucleic acid (CHEBI:16991) 97: Alkylation, DNA
73 increased mutation (MESH:D009154) deoxyribonucleic acid (CHEBI:16991)
74 functional change DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) None
721 increased DNA molecule region (FMA:84119) None
864 increased abnormal DNA repair (MP:0008058) DNA repair complex (GO:1990391) 1669: Increased, DNA damage and mutation
290 decreased dopamine beta-monooxygenase activity (GO:0004500) dopamine beta-hydroxylase (PR:000006294) 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase
568 increased synaptic transmission, dopaminergic (GO:0001963) dopaminergic neuron (CL:0000700) 1083: Decreased, Dopaminergic activity
983 decreased postsynaptic actin cytoskeleton organization (GO:0098974) drebrin (PR:000006296) 2078: Loss of drebrin
1097 decreased Dementia (HP:0000726) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1098 decreased long term synaptic depression (GO:0060292) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1099 increased abnormal long term potentiation (MP:0002207) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
606 decreased catalytic activity (GO:0003824) dual oxidase 1 (PR:000006727) 1156: Inhibition, Dual oxidase
621 increased Dyspnea (MESH:D004417) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
12 increased ecdysone receptor-mediated signaling pathway (GO:0035076) ecdysone receptor holocomplex (GO:0008230) 103: Increase, Ecdysone receptor hyperactivation
134 decreased eggshell (UBERON:0005079) 106: Reduction, Eggshell thickness
135 functional change eggshell (UBERON:0005079) 119: N/A, Gap
17 increased gene expression (GO:0010467) Eip75B protein, Drosophila (MESH:C061375) 1264: Increase, Nuclear receptor E75b gene expression
198 increased protein binding (GO:0005515) electrophilic reagant (CHEBI:59739) 396: Covalent Binding, Protein
1109 increased Metaplasia (MESH:D008679) endometrium epithelium (UBERON:0004811) 1068: Endometrial squamous metaplasia, Increase
946 occurrence pH reduction (GO:0045851) endosome (GO:0005768) None
901 functional change nitric oxide homeostasis (GO:0033484) endothelium (UBERON:0001986) 2067: Altered, Nitric Oxide Levels
803 occurrence phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) None