Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 26 to 50 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
60 abnormal dendrite morphogenesis (GO:0048813) dendrite (GO:0030425) 382: Aberrant, Dendritic morphology
321 abnormal calmodulin binding (GO:0005516) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
371 abnormal chromosome movement towards spindle pole (GO:0051305) chromosome (GO:0005694) 752: Altered, Meiotic chromosome dynamics
279 abnormal fetal proteins (MESH:D005326) 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
209 abnormal cell proliferation (GO:0008283) Liver cell (FMA:63179) 854: Alterations, Cellular proliferation / hyperplasia
578 abnormal role (MESH:D012380) 1108: Abnormal, Role change within caste
206 abnormal cellular homeostasis (GO:0019725) 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis
304 abnormal binding (GO:0005488) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
302 abnormal foraging behavior (GO:0060756) 560: Abnormal, Foraging activity and behavior
42 abnormal regulation of gene expression (GO:0010468) hippocampal formation (UBERON:0002421) 756: Hippocampal gene expression, Altered
495 abnormal cardiovascular system development (GO:0072358) cardiovascular system (UBERON:0004535) 317: Altered, Cardiovascular development/function
310 abnormal DNA repair (GO:0006281) Mitochondrial deoxyribonucleic acid (FMA:67199) 664: Overwhelmed, Mitochondrial DNA repair mechanisms
581 abnormal wound healing (GO:0042060) 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
136 abnormal multi-organism reproductive process (GO:0044703) 253: N/A, Reproductive failure
269 abnormal anatomical structure development (GO:0048856) nervous system (UBERON:0001016) 186: Altered, Neuroanatomy
143 abnormal developmental process (GO:0032502) reproductive organ (UBERON:0003133) 364: Impaired development of, Reproductive organs
142 abnormal larval development (GO:0002164)
231 abnormal sex ratio (MESH:D012744) 417: skewed, sex ratio
28 abnormal abnormal lipid homeostasis (MP:0002118) 862: Not Increased, Circulating Ketone Bodies
289 abnormal regulation of steroid biosynthetic process (GO:0050810) 652: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
288 abnormal glucocorticoid receptor activity (GO:0004883) glucocorticoid receptor (PR:000011406) 651: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
146 abnormal gene expression (GO:0010467) hemoglobin subunit alpha (human) (PR:P69905) 21: Altered regulation, Alpha hemoglobin
580 abnormal hemostasis (GO:0007599) 1122: Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis
317 abnormal developmental process (GO:0032502) 577: impaired, Development
427 abnormal signaling (GO:0023052) hypoxia-inducible factor 1-alpha (PR:000008555) 801: modulation, Unknown