Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 26 to 50 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
721 increased DNA molecule region (FMA:84119) None
736 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron part (GO:0097458) None
509 decreased neurotransmitter secretion (GO:0007269) metastasis-suppressor KiSS-1 (rat) (PR:Q7TSB7) None
718 decreased hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) von Hippel-Lindau disease tumor suppressor (PR:000017294) None
103 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) None
556 morphological change Metaplasia (MESH:D008679) None
74 functional change DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) None
755 increased viral RNA genome replication (GO:0039694) None
474 decreased epithelial cell apoptotic process (GO:1904019) None
187 increased fatty liver (MESH:D005234) None
691 increased acute inflammatory response (GO:0002526) Cytokine (FMA:84050) None
579 increased reactive oxygen species (CHEBI:26523) None
730 decreased activin receptor signaling pathway (GO:0032924) activin receptor complex (GO:0048179) None
726 decreased androgen biosynthetic process (GO:0006702) None
704 decreased testicular atrophy (MP:0003205) Testis (FMA:7210) None
102 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) None
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
482 occurrence mucus secretion (GO:0070254) None
429 decreased cholesterol (CHEBI:16113) None
560 delayed estrus (GO:0060209) None
696 decreased vascular endothelial growth factor A (PR:000017284) None
667 increased biosynthetic process (GO:0009058) reactive oxygen species (CHEBI:26523) None
523 decreased survival (MESH:D013534) None
719 increased hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) None
177 functional change mitochondrion disassembly (GO:0061726) mitochondrion (GO:0005739) None