Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 26 to 50 of 1146 KECs

ID	Action	Object	Associated Key Events (KEs)


178	occurrence	fatty liver (MESH:D005234)	345: N/A, Liver Steatosis
163	increased	hepatocellular carcinoma (MESH:D006528)	3 Events 347: Formation, Liver tumor 856: Formation, Hepatocellular and Bile duct tumors 378: Tumorigenesis, Hepatocellular carcinoma
129	occurrence	cholestasis (MESH:D002779)	2 Events 357: Cholestasis, Pathology 1059: Increased, cholestasis
95	morphological change	male reproductive organ (UBERON:0003135)	348: Malformation, Male reproductive tract
297	abnormal	fertilization envelope (GO:0060387)	534: Altered, Formation of cortical envelope
138	increased	vitellogenins (MESH:D014819)	2 Events 220: Increase, Plasma vitellogenin concentrations 419: Increased, renal vitellogenin deposition
6	functional change	mitochondrion (GO:0005739)	2 Events 177: Increase, Mitochondrial dysfunction 2363: Elevated mitochondrial ROS and dysfunction
100	decreased	fertility (MESH:D005298)	6 Events 337: N/A, Impairment of reproductive capacity 505: Decreased sperm quantity / quality in the adult, Decreased fertility 520: Decreased sperm quantity or quality in the adult, Decreased fertility 527: Decreased, Decreased fecundity 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis 330: Decrease, Fertility
187	increased	fatty liver (MESH:D005234)	None
232	functional change	glomerular basement membrane (UBERON:0005777)	421: Increased, glomerular rupture and renal hemorrhaging
78	increased	decreased heart rate (MESH:D001919)	444: Increased, Atrioventricular block and bradycardia
11	occurrence	Parkinsonian disorders (MESH:D020734)	896: Parkinsonian motor deficits
132	decreased	prostaglandin E2 (CHEBI:15551)	2 Events 243: Reduction, Prostaglandin E2 concentration 687: Reduced, Prostaglandin E2 concentration, hypothalamus
208	occurrence	Liver Diseases (MESH:D008107)	139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
179	increased	membrane (GO:0016020)	46: Accumulation, Biological membranes
135	functional change	eggshell (UBERON:0005079)	119: N/A, Gap
134	decreased	eggshell (UBERON:0005079)	106: Reduction, Eggshell thickness
222	abnormal	capillary plexus (UBERON:0035753)	298: Insufficiency, Vascular
147	increased	hemolysis (MESH:D006461)	250: Damaging, Red blood cells; hemolysis
155	decreased	hemoglobin (CHEBI:35143)	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
86	decreased	glutathione (CHEBI:16856)	None
121	decreased	nitric oxide (CHEBI:16480)	193: Decreased, Nitric Oxide
76	increased	acetylcholine (CHEBI:15355)	10: Acetylcholine accumulation in synapses
279	abnormal	fetal proteins (MESH:D005326)	661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
271	increased	corticosterone (CHEBI:16827)	653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone