Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 26 to 50 of 1147 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


73	increased	mutation (MESH:D009154)	deoxyribonucleic acid (CHEBI:16991)	3 Events 185: Increase, Mutations 336: Increase, Heritable mutations in offspring 876: Increase, Mutations in Critical Genes
123	increased	oxidative stress (MP:0003674)		3 Events 209: Peptide Oxidation 1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK 1392: Increase, Oxidative Stress
266	increased	apoptotic process (GO:0006915)		3 Events 496: Increased apoptosis, decreased fetal/adult Leydig Cells 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells 1262: Apoptosis
81	increased	hyperactivity (MP:0001399)		3 Events 39: Increased Cholinergic Signaling 602: Increased, Ataxia, paralysis, or hyperactivity 764: N/A, Ataxia, paralysis, or hyperactivity
181	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor alpha (PR:000013056)	3 Events 231: Decreased, PPAR-alpha activation 468: Inhibition, PPAR alpha 1057: Increased, PPAR-alpha activation
622	increased	dermatitis (MP:0001194)		3 Events 1224: Non-neuronal production of TNF, Epithelial irritation 1234: Production of nerve growth factor , Epithelial irritation 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation
273	increased	abnormal fetal Leydig cell differentiation (MP:0013603)		3 Events 657: Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells 660: decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells 540: Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
137	increased	estrogen receptor activity (GO:0030284)	estrogen receptor (PR:000007204)	3 Events 111: Agonism, Estrogen receptor 659: Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists 748: Increased, Estrogen receptor (ER) activity
504	increased		thyroxine (CHEBI:30660)	3 Events 959: Increased, Free serum thyroxine (T4) 1093: Decreased, Thyroxine (T4) in tissues 958: Displacement, Serum thyroxine (T4) from transthyretin
1	increased	cell proliferation (GO:0008283)		3 Events 57: Proliferation, Cell proliferation in the absence of cytotoxicity 416: Increase proliferation, Leydig cell 1182: Increase, Cell Proliferation (Epithelial Cells)
192	occurrence	liver fibrosis (MP:0003333)	liver (UBERON:0002107)	2 Events 344: Increase, Liver fibrosis 840: Formation, Liver fibrosis
142	abnormal	larval development (GO:0002164)		2 Events 339: Altered, Larval development 566: impaired, Larval development
49	decreased	GABA-gated chloride ion channel activity (GO:0022851)	chloride (CHEBI:17996)	2 Events 64: Reduction, Ionotropic GABA receptor chloride channel conductance 762: Activation, ionotropic GABA Receptor chloride channel
130	decreased	prostaglandin-endoperoxide synthase activity (GO:0004666)	prostaglandin G/H synthase 1 (PR:000013427)	2 Events 79: Inhibition, Cyclooxygenase activity 1103: Inhibition, Cyclooxygenase 1 activity
151	increased		erythrocyte (CL:0000232)	2 Events 246: Increase, RBC congestion in liver 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
129	occurrence		cholestasis (MESH:D002779)	2 Events 357: Cholestasis, Pathology 1059: Increased, cholestasis
144	decreased	estrogen receptor activity (GO:0030284)	estrogen receptor (PR:000007204)	2 Events 112: Antagonism, Estrogen receptor 1046: Suppression, Estrogen receptor (ER) activity
6	functional change		mitochondrion (GO:0005739)	2 Events 177: Increase, Mitochondrial dysfunction 2363: Elevated mitochondrial ROS and dysfunction
174	increased	gene expression (GO:0010467)	acyl-CoA desaturase (PR:000014497)	2 Events 258: Activation, SCD-1 462: Up Regulation, SCD-1
167	increased	signaling (GO:0023052)	oxysterols receptor LXR-alpha (PR:000011395)	2 Events 167: Activation, LXR 483: Activation, LXR alpha
15	increased	muscle contraction (GO:0006936)		2 Events 993: Decrease, Abdominal muscle contraction 601: Overactivation, muscle contraction
183	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor gamma (PR:000013058)	2 Events 233: Decreased, PPAR-gamma activation 1028: Activation of specific nuclear receptors, PPAR-gamma activation
175	increased	fatty acid biosynthetic process (GO:0006633)	fatty acid (CHEBI:35366)	2 Events 89: Synthesis, De Novo Fatty Acid (FA) 458: Increased, De Novo FA synthesis
27	decreased	ketosis (MESH:D007662)		2 Events 861: Decreased, Ketogenesis (production of ketone bodies) 477: Decreased, Ketogenesis
186	decreased	3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857)	3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)	2 Events 8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene