Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 26 to 50 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
783 increased vasodilation (GO:0042311) 1867: Bradykinin system, hyperactivated
784 increased vascular inflammation (MP:0001863) 1867: Bradykinin system, hyperactivated
217 decreased vascular endothelial growth factor receptor 2 binding (GO:0043184) vascular endothelial growth factor receptor 2 (PR:000002112) 305: Inhibition, VegfR2
218 decreased vascular endothelial growth factor receptor 2 binding (GO:0043184) vascular endothelial growth factor receptor 1 (PR:000007563) 305: Inhibition, VegfR2
600 increased vascular calcification (MESH:D061205) vasculature (UBERON:0002049) 1151: Osteoporosis and vascular calcification, Bone deterioration
675 increased unsaturated fatty acid biosynthetic process (GO:0006636) unsaturated fatty acid (CHEBI:27208) 1285: Up Regulation, Unsaturated fatty acid
878 decreased type I interferon signaling pathway (GO:0060337) interferon alpha (PR:000024938) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
879 decreased type I interferon signaling pathway (GO:0060337) interferon beta (PR:000024939) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
787 decreased type I interferon signaling pathway (GO:0060337) signalling molecule (CHEBI:62488) None
833 increased tumor necrosis factor secretion (GO:1990774) tumor necrosis factor alpha (PR:000000134) 1868: Hyperinflammation
372 increased tubulin binding (GO:0015631) tubulin (PR:000028799) 718: Binding, Tubulin
246 increased triglyceride biosynthetic process (GO:0019432) triglyceride (CHEBI:17855) 454: Increased, Triglyceride formation
586 decreased transport (GO:0006810) nutrient (CHEBI:33284) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
608 increased transport (GO:0006810) thyroid hormone (CHEBI:60311) 1158: Increased, Hepatic thyroid hormone uptake/transport
124 decreased transport (GO:0006810) bile salt export pump (PR:000003549) 41: Inhibition, Bile Salt Export Pump (ABCB11)
636 decreased transport (GO:0006810) sodium(1+) (CHEBI:29101) 1176: Decreased, sodium conductance 2
637 decreased transport (GO:0006810) gamma-aminobutyric acid (CHEBI:16865) 1179: Decreased, GABA release
505 increased transport (GO:0006810) thyroxine (CHEBI:30660) 960: Increased, Uptake of thyroxine into tissue
957 occurrence transmission of virus (GO:0019089) 2194: Influenza A Virus (IAV) shedding and transmission
20 decreased transmission of nerve impulse (GO:0019226) motor neuron (CL:0000100) 1267: Decrease, Ecdysis motor program activity
662 occurrence Translocation, Genetic (MESH:D014178) 1253: MLL chromosomal translocation
804 increased translation (GO:0006412) mucin-5AC (PR:000031343) 962: Increase, Mucin production
652 abnormal translation (GO:0006412) protein (PR:000000001) 1240: Altered, Protein Production
1111 increased translation (GO:0006412) homeobox protein SIX1 (PR:000014896) 2330: Sine oculis homeobox 1 protein expression, increased
790 decreased translation (GO:0006412) None