Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 751 to 775 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
414 increased cell death (GO:0008219) hepatocyte (CL:0000182) 786: Increase, Cytotoxicity (hepatocytes)
415 increased cell proliferation (GO:0008283) hepatocyte (CL:0000182) 787: Increase, Regenerative cell proliferation (hepatocytes)
417 increased increased thyroid-stimulating hormone level (MP:0005135) Thyroid stimulating hormone (CHEBI:81567) 753: Increase, Thyroid-stimulating hormone (TSH)
419 increased cystolithiasis (MP:0011625) Calculi (MESH:D002137) 793: Increase, Urinary bladder calculi
420 increased cell death (GO:0008219) urothelial cell (CL:0000731) 794: Increase, Cytotoxicity (urothelial cells)
421 increased cell proliferation (GO:0008283) urothelial cell (CL:0000731) 795: Increase, Regenerative cell proliferation (urothelial cells)
422 increased hyperplasia (MESH:D006965) urothelial cell (CL:0000731) 796: Increase, Hyperplasia (urothelial)
424 increased gene expression (GO:0010467) hypoxia-inducible factor 1 (Caenorhabditis elegans) (PR:G5EGD2) 799: Increased, HIF-1 heterodimer
426 increased gene expression (GO:0010467) hypoxia-inducible factor 1-alpha (PR:000008555)
440 increased creatinine (CHEBI:16737) 813: Increased, Serum creatinine
441 increased abnormal amino acid level (MP:0005332) 813: Increased, Serum creatinine
448 increased Microvesicular hepatic steatosis (HP:0001414) 838: Induction, Microvesicular fat
452 increased porphyrins (CHEBI:26214) 846: Accumulation, Highly carboxylated porphyrins
453 increased gene expression (GO:0010467) cytochrome P450 1A2 (PR:000006102) 850: Induction, CYP1A2/CYP1A5
454 increased gene expression (GO:0010467) cytochrome P450 1A5 (chicken) (PR:P79761) 850: Induction, CYP1A2/CYP1A5
456 increased porphyria (MP:0005654) 369: Uroporphyria
457 increased uroporphyrinogen (CHEBI:27258) 844: Oxidation, Uroporphyrinogen
459 increased leukocyte mediated cytotoxicity (GO:0001909) 768: Increase, Cytotoxicity
460 increased atrophy (MESH:D001284) olfactory epithelium (UBERON:0001997) 868: Increase, Tissue Degeneration, Necrosis & Atrophy
461 increased necrotic cell death (GO:0070265)
462 increased Metaplasia (MESH:D008679) 869: Increase, Respiratory or Squamous Metaplasia
463 increased neoplasm (MP:0002006) olfactory segment of nasal mucosa (UBERON:0005386) 872: Increase, Site of Contact Nasal Tumors
465 increased uric acid (CHEBI:27226)
467 increased potassium atom (CHEBI:26216) 1098: Increased, blood potassium concentration
468 increased Arrhythmias, Cardiac (MESH:D001145) 1106: Occurrence, cardiac arrhythmia