Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 751 to 775 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
359 increased deactivation of mitotic spindle assembly checkpoint (GO:1902426) MAD2 like protein (fruit fly) (PR:Q9VNE1) 695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
286 abnormal cytoskeleton organization (GO:0007010) Leydig cell (CL:0000178) 649: Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
127 increased cytokine secretion (GO:0050663) Cytokine (FMA:84050) 87: Release, Cytokine
67 decreased cytokine production involved in inflammatory response (GO:0002534) 152: Suppression, Inflammatory cytokines
200 increased cytokine production involved in inflammatory response (GO:0002534) 826: Activation, Keratinocytes
513 decreased cytokine production involved in inflammatory response (GO:0002534) NFAT activation molecule 1 (PR:000011161) 981: Reduction, NFAT/AP-1 complex formation
853 increased cytokine production involved in inflammatory response (GO:0002534) Cytokine (FMA:84050) 1496: Increased, secretion of proinflammatory mediators
623 increased cytokine production (GO:0001816) tumor necrosis factor alpha (PR:000000134) 1224: Non-neuronal production of TNF, Epithelial irritation
626 increased cytokine production (GO:0001816) beta-nerve growth factor (PR:000011194) 1234: Production of nerve growth factor , Epithelial irritation
627 increased cytokine production (GO:0001816) interleukin-8 (PR:000001395) 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation
196 increased cytokine activity (GO:0005125) Cytokine (FMA:84050) 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
1086 decreased cytochrome-c oxidase activity (GO:0004129) mitochondrion (GO:0005739) 1840: Inhibition, cytochrome oxidase
419 increased cystolithiasis (MP:0011625) Calculi (MESH:D002137) 793: Increase, Urinary bladder calculi
749 decreased cuticle development (GO:0042335) cuticle (UBERON:0001002) 1523: Decrease, Cuticular chitin content
194 increased covalent binding (MI:0195) xenobiotic (CHEBI:35703) 75: N/A, Covalent binding to protein, possibly lysine residue
1074 occurrence cornification (GO:0070268) epithelium of vagina (UBERON:0001344) 2306: Persistent vaginal cornification
855 increased complement activation (GO:0006956) 1496: Increased, secretion of proinflammatory mediators
303 increased colony collapse (MESH:D056631)
188 increased collagen biosynthetic process (GO:0032964) collagen (CHEBI:3815) 68: Increase, Collagen accumulation
216 decreased cognition (GO:0050890) 402: Cognitive function, decreased
45 increased cochlear degeneration (MP:0000032) 319: Loss, Cochlear function
1023 increased CNS demyelination (HP:0007305) 2266: Demyelination, increased
895 increased cleft upper lip (MP:0005170) 2042: Increase, Orofacial clefting
894 increased Cleft palate (HP:0000175) 2042: Increase, Orofacial clefting
944 occurrence clathrin-dependent endocytosis (GO:0072583) None