Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 776 to 800 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
469 increased Neoplasms (MESH:D009369) 885: Increase, Cancer
472 increased phosphorylation (GO:0016310) transcription factor Sp1 (PR:000000133) 924: Activation, Sp1
478 increased cell proliferation (GO:0008283) goblet cell (CL:0000160) 923: Increase, Proliferation of goblet cells
479 increased gene expression (GO:0010467) mucin-5AC (PR:000031343) 962: Increase, Mucin production
480 increased secretion (GO:0046903) mucin-5AC (PR:000031343) None
488 increased increased systemic vascular resistance (MP:0004878) 951: KE8 : Increase, Vascular Resistance
489 increased hypertension (MP:0000231) 952: Hypertension
492 increased protein glutathionylation (GO:0010731) nitric oxide synthase, endothelial (PR:000011328) 927: KE1 : S-Glutathionylation, eNOS
493 increased protein glutathionylation (GO:0010731) cysteine residue (CHEBI:32460) 927: KE1 : S-Glutathionylation, eNOS
496 increased pericardial edema (MP:0001787) 358: Increase, Pericardial edema
497 increased embryonic lethality (MP:0008762) 947: Increase, Early Life Stage Mortality
499 increased protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) 944: dimerization, AHR/ARNT
500 increased protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) 944: dimerization, AHR/ARNT
503 increased binding (GO:0005488) transthyretin (PR:000016801) 957: Binding, Transthyretin in serum
504 increased thyroxine (CHEBI:30660)
505 increased transport (GO:0006810) thyroxine (CHEBI:30660) 960: Increased, Uptake of thyroxine into tissue
506 increased metabolic process (GO:0008152) thyroxine (CHEBI:30660) 961: Increased, Clearance of thyroxine from serum
512 increased genetic interference (MI:0254) NFAT protein (PR:000003112) 979: Interference, nuclear localization of NFAT
514 increased Immunosuppression (MESH:D007165) None
515 increased binding (GO:0005488) FK506-binding protein 15 (PR:000007535) 980: Inhibition, Calcineurin Activity
516 increased binding (GO:0005488) FKBP12 (Arabidopsis thaliana) (TAIR:AT5G64350) 980: Inhibition, Calcineurin Activity
517 increased binding (GO:0005488) Immunophilins (MESH:D020104) 1201: Binding, Immunophilins
527 increased inhibitory postsynaptic potential (GO:0060080) 1012: Increased, Inhibitory postsynaptic potential
529 increased gene expression (GO:0010467) UDP-glucuronosyltransferase (PR:000024849) 1020: Increased, induction of UDPGT's in liver
530 increased hormone catabolic process (GO:0042447) thyroxine (CHEBI:30660) 1021: Increased, T4/T3 catabolism