Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 776 to 800 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
782 increased increased vascular permeability (MP:0003070) 1867: Bradykinin system, hyperactivated
783 increased vasodilation (GO:0042311) 1867: Bradykinin system, hyperactivated
784 increased vascular inflammation (MP:0001863) 1867: Bradykinin system, hyperactivated
785 morphological change retina layer formation (GO:0010842) retina (UBERON:0000966) 1877: Altered, retinal layer structure
791 decreased chloride channel activity (GO:0005254) 1906: Cystic Fibrosis Transmembrane Regulator Function, Decreased
794 decreased mucociliary clearance trait (VT:0001947) 1909: Mucociliary Clearance, Decreased
797 increased oxidative phosphorylation uncoupler activity (GO:0017077) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
798 decreased regulation of mitochondrial membrane potential (GO:0051881) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
799 increased proton binding (GO:1901691) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
800 decreased epithelial lining fluid (UBERON:0035963) 1907: Airway Surface Liquid Height, Decreased
802 occurrence Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) 1908: Cilia Beat Frequency, Decreased
804 increased translation (GO:0006412) mucin-5AC (PR:000031343) 962: Increase, Mucin production
805 increased mucus secretion (GO:0070254) lung goblet cell (CL:1000143) 1251: Chronic, Mucus hypersecretion
806 increased NLRP3 inflammasome complex assembly (GO:0044546) NLRP3 inflammasome complex (GO:0072559) 1895: NLRP3 inflammasome activity, increased
807 decreased motile cilium (GO:0031514) 1912: Motile Cilia Number/Length, Decreased
808 decreased forkhead box protein J1 (PR:000007628) 1911: FOXJ1 Protein, Decreased
810 functional change vision trait (VT:0002090) eye (UBERON:0000970) 1643: Altered, Visual function
811 increased glycosylation (GO:0070085) mucin-5AC (PR:000031343) 1910: Mucus Viscosity, Increased
815 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
816 increased carboxypeptidase activity (GO:0004180) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
817 decreased protein localization to cell surface (GO:0034394) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
818 increased angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
819 increased phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) 941: Activation, EGFR
820 decreased apoptotic process (GO:0006915) ciliated epithelial cell (CL:0000067) 914: Decrease, Apoptosis of ciliated epithelial cells
823 increased synaptic transmission, glutamatergic (GO:0035249) L-glutamate(1-) (CHEBI:29985) 1350: Increased, glutamate