Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 776 to 800 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
780 increased negative regulation of fibrinolysis (GO:0051918) 1866: Fibrinolysis, decreased
980 pathological negative regulation of synaptic plasticity (GO:0031914) postsynaptic actin cytoskeleton (GO:0098871) 2242: Abnormality, dendritic spine morphology
528 decreased negative regulation of synaptic transmission (GO:0050805) GABA receptor complex (GO:1902710) 1015: Increased, Neuronal synaptic inhibition
391 increased neoplasm (MP:0002006) 745: Increase, Leydig cell tumors
463 increased neoplasm (MP:0002006) olfactory segment of nasal mucosa (UBERON:0005386) 872: Increase, Site of Contact Nasal Tumors
866 increased Neoplasm of the lung (HP:0100526) lung (UBERON:0002048) 1670: Lung cancer
234 increased Nephropathy (HP:0000112) 422: Increased, nephropathy
58 increased neurodegeneration (MP:0002229) 352: N/A, Neurodegeneration
995 decreased neurogenesis (GO:0022008) 2098: Increase, Abnormal Neural Remodeling
997 increased neuron death (GO:0070997) 2098: Increase, Abnormal Neural Remodeling
88 increased neuron death in response to oxidative stress (GO:0036475) 191: Neuronal dysfunction
617 increased neuropeptide hormone activity (GO:0005184) Substance P (CHEBI:80308) 1222: SP (Substance P) release, Local increase of SP
688 increased neuropeptide hormone activity (GO:0005184) Calcitonin gene-related peptide 1 (CHEBI:80337) 1433: Increased CGRP, neuronal release of CGRP
689 increased neuropeptide hormone activity (GO:0005184) Neurokinin A (CHEBI:80311) 1435: Increased neurokinin A (NKA) by neuronal cells
1136 decreased neuropeptide signaling pathway (GO:0007218) Metastin (CHEBI:80304) None
769 increased neuropilin binding (GO:0038191) None
849 increased neuropilin binding (GO:0038191) neuropilin-1 (PR:000001900) None
336 decreased neurotransmitter reuptake (GO:0098810) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
332 increased neurotransmitter secretion (GO:0007269) 600: Overactivation, Neuronotransmitter release
1120 decreased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 968: Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons
1138 increased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 1985: Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)
509 decreased neurotransmitter secretion (GO:0007269) metastasis-suppressor KiSS-1 (rat) (PR:Q7TSB7) None
859 increased neutrophil activation (GO:0042119) neutrophil (CL:0000775) None
487 decreased nitric oxide biosynthetic process (GO:0006809) nitric oxide (CHEBI:16480) 933: KE6 : Depletion, Nitric Oxide
901 functional change nitric oxide homeostasis (GO:0033484) endothelium (UBERON:0001986) 2067: Altered, Nitric Oxide Levels