Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 776 to 800 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
826 increased chronic inflammatory response (GO:0002544) 1868: Hyperinflammation
357 abnormal chromosome segregation (GO:0007059) 696: Increased, Chromosome misseggregation
371 abnormal chromosome movement towards spindle pole (GO:0051305) chromosome (GO:0005694) 752: Altered, Meiotic chromosome dynamics
862 increased chromosome breakage (GO:0031052) chromosome (GO:0005694)
863 increased chromosomal instability (MP:0008866) chromosome (GO:0005694)
734 decreased cholesterol transport (GO:0030301) cholesterol (CHEBI:16113) 807: Decreased, cholesterol
735 decreased cholesterol transport (GO:0030301) cholesteryl ester (CHEBI:17002) 807: Decreased, cholesterol
280 decreased cholesterol biosynthetic process (GO:0006695) cholesterol (CHEBI:16113)
1026 increased cholesterol biosynthetic process (GO:0006695) 2270: Increased, cholesterol synthesis enzymes
399 increased chloride transmembrane transport (GO:1902476) chloride (CHEBI:17996) 761: Increased, Chloride conductance
397 increased chloride channel activity (GO:0005254) glutamate-gated chloride channel (fruit fly) (PR:Q94900)
791 decreased chloride channel activity (GO:0005254) 1906: Cystic Fibrosis Transmembrane Regulator Function, Decreased
751 decreased chitin synthase activity (GO:0004100) 1522: Inhibition, Chitin synthase 1
14 increased chitin biosynthetic process (GO:0006031) chitin (CHEBI:17029) 990: Increase, Incomplete ecdysis
854 increased chemokine secretion (GO:0090195) Chemokine (FMA:241981) 1496: Increased, secretion of proinflammatory mediators
195 increased chemokine activity (GO:0008009) Chemokine (FMA:241981) 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
44 abnormal chemical synaptic transmission (GO:0007268) None
51 decreased chemical synaptic transmission (GO:0007268) 669: Reduction, Neuronal synaptic inhibition
708 abnormal chemical synaptic transmission (GO:0007268) synapse (GO:0045202) 758: Hippocampal Physiology, Altered
788 decreased cellular response to type I interferon (GO:0071357) type I interferon receptor complex (GO:0038197) None
764 increased cellular response to oxidative stress (GO:0034599) reactive oxygen species (CHEBI:26523) 1869: Diminished protective oxidative stress response
714 increased cellular response to oxidative stress (GO:0034599) 1394: Induction, persistent proliferation/sustained proliferation
1110 decreased cellular response to oxidative stress (GO:0034599) 1869: Diminished protective oxidative stress response
880 occurrence cellular response to exogenous dsRNA (GO:0071360) RNA viral genome (GO:0019022) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
378 increased cellular respiration (GO:0045333) 769: Increase, Oxidative metabolism