Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 801 to 825 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
824 increased viral release from host cell (GO:0019076) 1939: Viral infection and host-to-host transmission, proliferated
825 abnormal otic vesicle formation (GO:0030916) 1930: altered, inner ear development
826 increased chronic inflammatory response (GO:0002544) 1868: Hyperinflammation
830 increased regulation of chronic inflammatory response (GO:0002676) 1868: Hyperinflammation
831 increased interleukin-6 production (GO:0032635) interleukin-6 (PR:000001393) 1868: Hyperinflammation
832 increased interleukin-1 beta production (GO:0032611) interleukin-1 beta (PR:000001136) 1868: Hyperinflammation
833 increased tumor necrosis factor secretion (GO:1990774) tumor necrosis factor alpha (PR:000000134) 1868: Hyperinflammation
834 increased Increased inflammatory response (HP:0012649) 1868: Hyperinflammation
835 increased Increased serum ferritin (HP:0003281) Ferritin (CHEBI:82594) 1868: Hyperinflammation
836 increased lactate dehydrogenase activity (GO:0004457) 1868: Hyperinflammation
837 increased Elevated C-reactive protein level (HP:0011227) C-reactive protein (PR:000005897) 1868: Hyperinflammation
838 decreased Lymphopenia (HP:0001888) lymphocyte (CL:0000542) 1868: Hyperinflammation
839 disrupted barrier epithelial cell (CL:0000073) 1931: Intestinal barrier, disruption
842 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 3 (PR:000015718) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
843 increased estrogen secretion (GO:0035937) Estrogen (FMA:83376) 1973: Increased, estrogens
845 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 4 (PR:000015719) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
846 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 5 (PR:000015720) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
847 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 6 (PR:000015721) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
851 disrupted action potential (GO:0001508) 1983: Disruption, action potential generation
853 increased cytokine production involved in inflammatory response (GO:0002534) Cytokine (FMA:84050) 1496: Increased, secretion of proinflammatory mediators
854 increased chemokine secretion (GO:0090195) Chemokine (FMA:241981) 1496: Increased, secretion of proinflammatory mediators
855 increased complement activation (GO:0006956) 1496: Increased, secretion of proinflammatory mediators
856 increased Interleukin (FMA:86578) 1496: Increased, secretion of proinflammatory mediators
857 increased inflammatory response (GO:0006954) inflammatory cell (CL:0009002) 1497: Increased, recruitment of inflammatory cells
858 increased macrophage activation (GO:0042116) macrophage (CL:0000235) 1497: Increased, recruitment of inflammatory cells