Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 801 to 825 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
154 increased Methemoglobinemia (MESH:D008708) 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
428 decreased mevalonate (CHEBI:25350) 805: Decreased, mevalonate
8 pathological brain inflammation (MP:0001847) microglial cell (CL:0000129) 188: Neuroinflammation
258 increased signaling (GO:0023052) microsomal triglyceride transfer protein large subunit MTTP (PR:000003392) 879: Activation, MTTP
373 increased microtubule depolymerization (GO:0007019) microtubule (GO:0005874) 720: Disruption, Microtubule dynamics
308 functional change response to wounding (GO:0009611) Mitochondrial deoxyribonucleic acid (FMA:67199) 570: Accumulation, Damaged mitochondrial DNA
310 abnormal DNA repair (GO:0006281) Mitochondrial deoxyribonucleic acid (FMA:67199) 664: Overwhelmed, Mitochondrial DNA repair mechanisms
118 disrupted mitochondrial respiratory chain (GO:0005746) 178: Mitochondrial electron transport chain, disrupted
1115 decreased Decreased activity of mitochondrial complex III (HP:0011924) mitochondrial respiratory chain complex III (GO:0005750) 1542: Inhibition, Mitochondrial complex III
1086 decreased cytochrome-c oxidase activity (GO:0004129) mitochondrion (GO:0005739) 1840: Inhibition, cytochrome oxidase
6 functional change mitochondrion (GO:0005739)
177 functional change mitochondrion disassembly (GO:0061726) mitochondrion (GO:0005739) None
795 decreased mitochondrion (GO:0005739) None
796 decreased ATP synthesis coupled proton transport (GO:0015986) mitochondrion (GO:0005739) None
797 increased oxidative phosphorylation uncoupler activity (GO:0017077) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
798 decreased regulation of mitochondrial membrane potential (GO:0051881) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
799 increased proton binding (GO:1901691) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
664 decreased function (MI:0613) mitochondrion (GO:0005739) 1260: Direct mitochondrial inhibition
375 increased cell proliferation (GO:0008283) mitogenic signaling cell (CL:0000422) 716: Increase, cell proliferation (hepatocytes)
1014 decreased thyroid hormone transport (GO:0070327) monocarboxylate transporter 8 (PR:000014950) 2258: Inhibition, monocarboxylate transporter 8 (MCT8)
801 decreased Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) None
802 occurrence Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) 1908: Cilia Beat Frequency, Decreased
807 decreased motile cilium (GO:0031514) 1912: Motile Cilia Number/Length, Decreased
20 decreased transmission of nerve impulse (GO:0019226) motor neuron (CL:0000100) 1267: Decrease, Ecdysis motor program activity
804 increased translation (GO:0006412) mucin-5AC (PR:000031343) 962: Increase, Mucin production