Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 801 to 825 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
160 decreased nitric-oxide synthase activity (GO:0004517) nitric oxide synthase, brain (PR:000011326) 147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307
806 increased NLRP3 inflammasome complex assembly (GO:0044546) NLRP3 inflammasome complex (GO:0072559) 1895: NLRP3 inflammasome activity, increased
1100 increased NMDA glutamate receptor activity (GO:0004972) None
685 decreased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 195: Inhibition, NMDARs
686 increased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 388: Overactivation, NMDARs
434 decreased norepinephrine binding (GO:0051380) (R)-noradrenaline (CHEBI:18357) 848: Decreased, Binding of NE to NE receptors on GnRH neurons
291 decreased norepinephrine biosynthetic process (GO:0042421) (R)-noradrenaline (CHEBI:18357) 528: Decreased, Synthesis of NE
950 occurrence nuclear export (GO:0051168) viral genome (GO:0019015) None
657 increased offspring quantity (VT:1000189) 1208: Increased, Male offspring
113 decreased oocyte development (GO:0048599) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
112 decreased oocyte growth (GO:0001555) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
470 occurrence organelle disassembly (GO:1903008) lysosome (GO:0005764) 898: Disruption, Lysosome
1004 decreased osteoblast differentiation (GO:0001649) 2089: Altered Bone Cell Homeostasis
1005 increased osteoclast differentiation (GO:0030316) 2089: Altered Bone Cell Homeostasis
599 increased osteoporosis (MP:0000066) 1151: Osteoporosis and vascular calcification, Bone deterioration
825 abnormal otic vesicle formation (GO:0030916) 1930: altered, inner ear development
1061 decreased ovarian follicle development (GO:0001541) ovarian follicle (UBERON:0001305) 1883: Decreased, size of the ovarian reserve
1094 decreased ovarian follicle development (GO:0001541) granulosa cell (CL:0000501) 1800: Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
1065 decreased ovulation (GO:0030728) Ovum (FMA:67343) 1695: Impaired ovulation
262 decreased ovulation (GO:0030728) 488: Decrease, Ovulation
36 disrupted ovulation cycle (GO:0042698) None
511 abnormal ovulation cycle (GO:0042698) 971: Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
1063 disrupted ovulation cycle (GO:0042698) ovarian follicle (UBERON:0001305) 405: disrupted, ovarian cycle
632 increased oxidation-reduction process (GO:0055114) plasma membrane (GO:0005886) 1238: Activation of oxidative stress pathway
633 increased oxidation-reduction process (GO:0055114) protein (PR:000000001) 1238: Activation of oxidative stress pathway