Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 826 to 850 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
563 increased mammary gland hyperplasia (MP:0000630) 1078: Hyperplasia, Mammary gland
564 increased abnormal tumor latency (MP:0010307) 1080: Increased, latency period
565 increased hyperplasia (MESH:D006965) prolactin secreting cell (CL:0000439) 1081: Increased, lactotroph hyperplasia and hypertrophy
566 increased hypertrophy (MESH:D006984) prolactin secreting cell (CL:0000439) 1081: Increased, lactotroph hyperplasia and hypertrophy
567 increased Pituitary adenoma (HP:0002893) Adenoma (MESH:D000236) 1082: Increased, adenomas (pituitary)
568 increased synaptic transmission, dopaminergic (GO:0001963) dopaminergic neuron (CL:0000700) 1083: Decreased, Dopaminergic activity
569 increased prolactin secretion (GO:0070459) prolactin (PR:000013246) 1084: Increased, prolactin secretion
570 increased hyperplasia (MESH:D006965) mammary gland (UBERON:0001911) 1085: Increased, hyperplasia (mammary gland)
571 increased cell death (GO:0008219) pleura (UBERON:0000977) 1086: persistent, cytotoxicity (pleura or peritoneum)
572 increased cell proliferation (GO:0008283) mesothelium (UBERON:0001136) 1089: Increased, Cell Proliferation (mesothelium)
573 increased mesothelioma (MESH:D008654) None
574 increased metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
575 increased 3,3',5-triiodo-L-thyronine (CHEBI:18258) 1116: Decreased, Triiodothyronine (T3) in tissues
577 increased Viral load (MESH:D019562) 1109: Increased, Deformed Wing Virus levels
579 increased reactive oxygen species (CHEBI:26523) None
594 increased acidosis (MP:0003031) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
595 increased hypovolemia (MP:0010128) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
598 increased oxidative phosphorylation uncoupler activity (GO:0017077) 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
599 increased osteoporosis (MP:0000066) 1151: Osteoporosis and vascular calcification, Bone deterioration
600 increased vascular calcification (MESH:D061205) vasculature (UBERON:0002049) 1151: Osteoporosis and vascular calcification, Bone deterioration
607 increased signaling (GO:0023052) protein (PR:000000001) 1157: Activation, Hepatic nuclear receptor(s)
608 increased transport (GO:0006810) thyroid hormone (CHEBI:60311) 1158: Increased, Hepatic thyroid hormone uptake/transport
609 increased catalytic activity (GO:0003824) beta-1,3-glucuronyltransferase (PR:000001325) 295: Induction, Upregulation of glucuronyltransferase activity
610 increased cell maturation (GO:0048469) gamete (CL:0000300) 1161: Increased, oocyte maturation
611 increased reproductive process (GO:0022414) 1163: Increased, Reproductive Success