Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 826 to 850 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
811 increased glycosylation (GO:0070085) mucin-5AC (PR:000031343) 1910: Mucus Viscosity, Increased
479 increased gene expression (GO:0010467) mucin-5AC (PR:000031343) 962: Increase, Mucin production
480 increased secretion (GO:0046903) mucin-5AC (PR:000031343) None
753 decreased growth (GO:0040007) multicellular organism (UBERON:0000468) 1521: Decrease, Growth
724 increased G-protein coupled acetylcholine receptor binding (GO:0031789) muscarinic acetylcholine receptor (PR:000001488) 1602: Increased Muscarinic Acetylcholine Receptors
30 increased protein catabolic process (GO:0030163) muscle protein (MESH:D009124) 863: Increased, Catabolism of Muscle Protein
1149 increased androgen receptor signaling pathway (GO:0030521) Musculature of female perineum (FMA:264623) 2365: Anogenital distance (AGD), increased
732 disrupted androgen receptor signaling pathway (GO:0030521) Musculature of male perineum (FMA:264621) 1688: anogenital distance (AGD), decreased
4 decreased mitochondrial electron transport, NADH to ubiquinone (GO:0006120) NADH-ubiquinone oxidoreductase chain 1 (PR:000031316) 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
5 decreased NADH dehydrogenase (ubiquinone) activity (GO:0008137) NADH-ubiquinone oxidoreductase chain 1 (PR:000031316) 887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)
666 increased signaling (GO:0023052) NADPH Oxidase (MESH:D019255) 1174: Activation, NADPH Oxidase
469 increased Neoplasms (MESH:D009369) 885: Increase, Cancer
365 increased epithelial cell proliferation (GO:0050673) nephron tubule epithelial cell (CL:1000494) None
411 increased cell death (GO:0008219) nephron tubule epithelial cell (CL:1000494) 783: Increase, Cytotoxicity (tubular epithelial cells)
412 increased kidney epithelium hyperplasia (MP:0004968) nephron tubule epithelial cell (CL:1000494) 784: Increase, Hyperplasia (tubular epithelial cells)
269 abnormal anatomical structure development (GO:0048856) nervous system (UBERON:0001016) 186: Altered, Neuroanatomy
689 increased neuropeptide hormone activity (GO:0005184) Neurokinin A (CHEBI:80311) 1435: Increased neurokinin A (NKA) by neuronal cells
737 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron (CL:0000540) 1623: Occurrence, Focal Seizure
736 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron part (GO:0097458) None
1020 decreased neuropathy target esterase (PR:000012946) 2262: Neuropathy target esterase, inhibited
849 increased neuropilin binding (GO:0038191) neuropilin-1 (PR:000001900) None
923 decreased signaling (GO:0023052) neurotransmitter (CHEBI:25512) 2151: Disruption, neurotransmitter release
859 increased neutrophil activation (GO:0042119) neutrophil (CL:0000775) None
69 increased I-kappaB phosphorylation (GO:0007252) NF-kappa-B inhibitor (PR:000003292) 145: Induction, IKB inhibitory protein
513 decreased cytokine production involved in inflammatory response (GO:0002534) NFAT activation molecule 1 (PR:000011161) 981: Reduction, NFAT/AP-1 complex formation