Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 826 to 850 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
892 decreased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) None
1095 increased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) 2041: Decrease, facial prominence outgrowth
1096 increased palatal shelves fail to meet at midline (MP:0009888) secondary palate (UBERON:0001716) 2041: Decrease, facial prominence outgrowth
82 increased paralysis (MP:0000753)
786 decreased pattern recognition receptor signaling pathway (GO:0002221) RNA viral genome (GO:0019022) None
868 increased pattern recognition receptor signaling pathway (GO:0002221) 1495: Substance interaction with the lung resident cell membrane components
1114 increased peptide biosynthetic process (GO:0043043) 2371: Increased cortisol
19 decreased peptide secretion (GO:0002790) cardioactive peptide (fruit fly) (PR:Q9VCW0) 1266: Decrease, Circulating crustacean cardioactive peptide
496 increased pericardial edema (MP:0001787) 358: Increase, Pericardial edema
89 increased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor alpha (PR:000013056) 227: Activation, PPARĪ±
168 increased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor gamma (PR:000013058) 228: peroxisome proliferator activated receptor promoter demethylation
181 decreased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor alpha (PR:000013056)
182 decreased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor delta (PR:000013057) 232: Decreased, PPAR-beta activation
183 decreased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor gamma (PR:000013058)
975 disrupted peroxisome proliferator activated receptor signaling pathway (GO:0035357) 2227: Disrupted PPAR isoform nuclear signaling
946 occurrence pH reduction (GO:0045851) endosome (GO:0005768) None
720 decreased phagocytosis (GO:0006909) macrophage (CL:0000235) 1668: Frustrated phagocytosis
449 decreased phospholipase activity (GO:0004620) phospholipase A1 member A (human) (PR:Q53H76) 828: Inhibition, Phospholipase A
472 increased phosphorylation (GO:0016310) transcription factor Sp1 (PR:000000133) 924: Activation, Sp1
803 occurrence phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) None
819 increased phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) 941: Activation, EGFR
567 increased Pituitary adenoma (HP:0002893) Adenoma (MESH:D000236) 1082: Increased, adenomas (pituitary)
665 abnormal plasma membrane organization (GO:0007009) 1259: narcosis
445 occurrence podocyte vacuolization (MP:0011899) 824: Occurrence, Cytoplasmic vacuolization (podocyte)
739 decreased population growth rate (PCO:0000008) population of organisms (PCO:0000001) 360: Decrease, Population growth rate