Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 851 to 875 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
83 decreased population growth rate (PCO:0000008)
456 increased porphyria (MP:0005654) 369: Uroporphyria
1002 occurrence positive regulation of bone resorption (GO:0045780) 2090: Increase, Bone Remodeling
170 increased positive regulation of fatty acid transport (GO:2000193) fatty acid (CHEBI:35366) 115: Increase, Fatty acid influx
700 increased positive regulation of gene expression (GO:0010628) cyclin-dependent kinase inhibitor (PR:000000014) 1504: p21 (CDKN1A) expression, increase
757 increased positive stranded viral RNA replication (GO:0039690) viral RNA-directed RNA polymerase complex (GO:0031381) 1847: Increased SARS-CoV-2 production
601 abnormal post-translational protein modification (GO:0043687) osteocalcin (PR:000030444) 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
983 decreased postsynaptic actin cytoskeleton organization (GO:0098974) drebrin (PR:000006296) 2078: Loss of drebrin
331 decreased potassium channel inhibitor activity (GO:0019870) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
324 increased predatory behavior (GO:0002120)
1087 decreased Premature ovarian failure (HP:0008209) ovarian follicle (UBERON:0001305) 2305: Premature ovarian Insufficiency
376 increased preneoplasia (MP:0002009) abnormal cell mass (MP:0003902) 774: Increase, Preneoplastic foci (hepatocytes)
394 decreased progesterone secretion (GO:0042701) progesterone (CHEBI:17026) 749: Decreased, Progesterone from corpus luteum
569 increased prolactin secretion (GO:0070459) prolactin (PR:000013246) 1084: Increased, prolactin secretion
1118 increased prolonged estrous cycle (MP:0009006) 1075: prolonged, estrus cycle
1119 increased prolonged estrus (MP:0009017) 1075: prolonged, estrus cycle
347 decreased prostaglandin biosynthetic process (GO:0001516) prostaglandin F2alpha (CHEBI:15553)
130 decreased prostaglandin-endoperoxide synthase activity (GO:0004666) prostaglandin G/H synthase 1 (PR:000013427)
131 decreased prostaglandin-endoperoxide synthase activity (GO:0004666) prostaglandin G/H synthase 2 (PR:000013428) 79: Inhibition, Cyclooxygenase activity
768 increased protease binding (GO:0002020) None
850 increased protease binding (GO:0002020) transmembrane protease serine 2 (human) (PR:O15393) None
874 occurrence protease binding (GO:0002020) transmembrane protease serine 2 (PR:000016456) None
484 decreased proteasome complex disassembly (GO:1903009) GTP cyclohydrolase 1 (PR:000007893) 935: KE2 : Decrease, GTPCH-1
190 increased protein alkylation (GO:0008213) 244: Alkylation, Protein
84 occurrence protein binding (GO:0005515) Selenium-Binding Proteins (MESH:D051137) 261: Binding, SH-/selen-proteins