Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 851 to 875 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
955 occurrence modulation by virus of host immune response (GO:0075528) 2180: Immune mechanisms antagonized by viral proteins
956 occurrence viral budding from plasma membrane (GO:0046761) 2193: Influenza A Virus (IAV) budding
957 occurrence transmission of virus (GO:0019089) 2194: Influenza A Virus (IAV) shedding and transmission
958 increased Breast carcinoma (HP:0003002) VEGF-A complex (GO:1990150) 1376: Increase, angiogenesis
959 increased Breast carcinoma (HP:0003002) BRCA1-A complex (GO:0070531) 1971: Increased, tumor growth
960 increased Hepatic steatosis (HP:0001397) 459: Increase, Liver steatosis
962 increased lipid oxidation (GO:0034440) polyunsaturated fatty acid (CHEBI:26208) 1445: Increase, Lipid peroxidation
963 increased Abnormality of the testis (HP:0000035) Testis (FMA:7210) 2206: Increased, histomorphological alteration of testis
964 decreased viable offspring quantity (VT:1000181) 2147: Decreased, Viable Offspring
966 abnormal animal organ formation (GO:0048645) epididymis (UBERON:0001301) 2212: Epididymal agenesis
967 decreased hormone biosynthetic process (GO:0042446) 17beta-Hydroxy-2-oxa-5alpha-androstan-3-one (CHEBI:79436) 1613: Decrease, dihydrotestosterone (DHT) levels
968 abnormal animal organ formation (GO:0048645) urethra (UBERON:0000057) 2213: Impaired, urethral tube closure
970 increased increased apoptosis (MP:0006042) 1513: General Apoptosis
973 abnormal animal organ development (GO:0048513) 1616: Malformation, cryptorchidism - maldescended testis
974 occurrence epithelial to mesenchymal transition (GO:0001837) Epithelial cell (FMA:66768) 1457: Epithelial Mesenchymal Transition
975 disrupted peroxisome proliferator activated receptor signaling pathway (GO:0035357) 2227: Disrupted PPAR isoform nuclear signaling
976 disrupted regulation of gene expression (GO:0010468) 2224: Dysregulation of transcriptional expression within PPAR signaling network
977 disrupted lipid storage (GO:0019915) 2225: Disrupted Lipid Storage
978 decreased interleukin-1 receptor activity (GO:0004908) interleukin-1 receptor type I (PR:000001363) 1700: Impaired IL-1R1 signaling in T cell
979 abnormal animal organ development (GO:0048513) gonad (UBERON:0000991) 1615: Impaired inguinoscrotal testicular descent phase
980 pathological negative regulation of synaptic plasticity (GO:0031914) postsynaptic actin cytoskeleton (GO:0098871) 2242: Abnormality, dendritic spine morphology
981 morphological change abnormal excitatory postsynaptic current amplitude (MP:0011267) dendritic spine membrane (GO:0032591) 388: Overactivation, NMDARs
983 decreased postsynaptic actin cytoskeleton organization (GO:0098974) drebrin (PR:000006296) 2078: Loss of drebrin
984 disrupted synapse (GO:0045202) 2005: Altered neurotransmission in development
985 disrupted voltage-gated sodium channel activity (GO:0005248) 1353: Binding to voltage-gated sodium channel