Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 876 to 900 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
930 occurrence protein localization to endosome (GO:0036010) clathrin-coated vesicle membrane (GO:0030665) 2159: Influenza A virus (IAV) cell entry
931 occurrence receptor-mediated endocytosis (GO:0006898) influenzavirus hemagglutinin (PR:000049750) 2159: Influenza A virus (IAV) cell entry
932 occurrence membrane fusion (GO:0061025) vesicle membrane (GO:0012506) 2159: Influenza A virus (IAV) cell entry
937 decreased toll-like receptor 7 signaling pathway (GO:0034154) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
938 decreased toll-like receptor 3 signaling pathway (GO:0034138) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
939 decreased sexual reproduction (GO:0019953) 2147: Decreased, Viable Offspring
940 decreased decreased body weight (MP:0001262) 864: Decreased, Body Weight
942 increased Atherosclerosis (HP:0002621) 1443: Atherosclerosis
948 occurrence protein import into nucleus (GO:0006606) viral RNA-directed RNA polymerase complex (GO:0031381) 2192: Influenza A Virus production increased
949 occurrence transcription, RNA-templated (GO:0001172) segmented viral genome (GO:0019017) 2192: Influenza A Virus production increased
951 occurrence viral mRNA export from host cell nucleus (GO:0046784) 2192: Influenza A Virus production increased
952 occurrence virus maturation (GO:0019075) 2192: Influenza A Virus production increased
953 occurrence suppression by virus of host cytokine production (GO:0046775) 2180: Immune mechanisms antagonized by viral proteins
954 occurrence virus induced gene silencing (GO:0009616) 2180: Immune mechanisms antagonized by viral proteins
955 occurrence modulation by virus of host immune response (GO:0075528) 2180: Immune mechanisms antagonized by viral proteins
956 occurrence viral budding from plasma membrane (GO:0046761) 2193: Influenza A Virus (IAV) budding
957 occurrence transmission of virus (GO:0019089) 2194: Influenza A Virus (IAV) shedding and transmission
958 increased Breast carcinoma (HP:0003002) VEGF-A complex (GO:1990150) 1376: Increase, angiogenesis
959 increased Breast carcinoma (HP:0003002) BRCA1-A complex (GO:0070531) 1971: Increased, tumor growth
960 increased Hepatic steatosis (HP:0001397) 459: Increase, Liver steatosis
962 increased lipid oxidation (GO:0034440) polyunsaturated fatty acid (CHEBI:26208) 1445: Increase, Lipid peroxidation
963 increased Abnormality of the testis (HP:0000035) Testis (FMA:7210) 2206: Increased, histomorphological alteration of testis
964 decreased viable offspring quantity (VT:1000181) 2147: Decreased, Viable Offspring
966 abnormal animal organ formation (GO:0048645) epididymis (UBERON:0001301) 2212: Epididymal agenesis
967 decreased hormone biosynthetic process (GO:0042446) 17beta-Hydroxy-2-oxa-5alpha-androstan-3-one (CHEBI:79436) 1613: Decrease, dihydrotestosterone (DHT) levels