Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 876 to 900 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
986 functional change sodium channel activity (GO:0005272) voltage-gated sodium channel complex (GO:0001518) 1977: Disruption of sodium channel gating kinetics
989 increased blood viscosity trait (VT:3000004) blood (UBERON:0000178) 2238: Increased, Blood viscosity
991 occurrence Cardiac arrest (HP:0001695) heart (UBERON:0000948) 1535: Heart failure
992 increased estradiol (CHEBI:23965) 2251: Estradiol availability, increased
993 increased energy deposition event (RBO:00015021) 1686: Deposition of Energy
994 increased DNA Strand Break (NCI:C25830) Deoxyribonucleic acid (FMA:74412) 1635: Increase, DNA strand breaks
995 decreased neurogenesis (GO:0022008) 2098: Increase, Abnormal Neural Remodeling
997 increased neuron death (GO:0070997) 2098: Increase, Abnormal Neural Remodeling
999 abnormal cell differentiation (GO:0030154) 2245: Altered Cell Differentiation Signaling
1000 abnormal DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 155: Inadequate DNA repair
1001 decreased bone mineralization (GO:0030282) 2090: Increase, Bone Remodeling
1002 occurrence positive regulation of bone resorption (GO:0045780) 2090: Increase, Bone Remodeling
1003 occurrence abnormal bone remodeling (MP:0002998) 2090: Increase, Bone Remodeling
1004 decreased osteoblast differentiation (GO:0001649) 2089: Altered Bone Cell Homeostasis
1005 increased osteoclast differentiation (GO:0030316) 2089: Altered Bone Cell Homeostasis
1006 increased cell death (GO:0008219) bone cell (CL:0001035) 1825: Increase, Cell death
1007 occurrence decreased trabecular bone volume (MP:0010879) 2091: Occurrence, Bone Loss
1008 occurrence decreased bone mineral density (MP:0000063) 2091: Occurrence, Bone Loss
1009 increased endothelial cell apoptotic process (GO:0072577) 2068: Increase, Endothelial Dysfunction
1010 increased protein modification process (GO:0036211) 2081: Increased Modified Proteins
1012 decreased sulfotransferase activity (GO:0008146) estrogen sulfotransferase (PR:000032783) 2155: Inhibition of Sulfotransferase E1 (SULT1E1)
1013 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) sodium:potassium-exchanging ATPase complex (GO:0005890) 1562: Decreased Na/K ATPase activity
1014 decreased thyroid hormone transport (GO:0070327) monocarboxylate transporter 8 (PR:000014950) 2258: Inhibition, monocarboxylate transporter 8 (MCT8)
1016 decreased sodium ion import (GO:0097369) gill (UBERON:0002535) 2236: Decreased, Sodium uptake in gills
1017 decreased decreased circulating sodium level (MP:0005634) blood plasma (UBERON:0001969) 2237: Decreased, Plasma sodium concentrations