Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 901 to 925 of 1152 KECs

ID	Action	Process	Associated Key Events (KEs)


378	increased	cellular respiration (GO:0045333)	769: Increase, Oxidative metabolism
391	increased	neoplasm (MP:0002006)	745: Increase, Leydig cell tumors
395	increased	synaptic transmission, dopaminergic (GO:0001963)	746: Increase, Dopaminergic activity
400	increased	membrane hyperpolarization (GO:0060081)	763: hyperpolarisation, neuron
436	decreased	glomerular filtration (GO:0003094)	819: Decreased, Glomerular filtration
437	decreased	kidney plasma flow trait (VT:0005524)	820: Decreased, Renal plasma flow
441	increased	abnormal amino acid level (MP:0005332)	813: Increased, Serum creatinine
445	occurrence	podocyte vacuolization (MP:0011899)	824: Occurrence, Cytoplasmic vacuolization (podocyte)
447	occurrence	Mallory bodies (MP:0014045)	839: Formation, Mallory body
448	increased	Microvesicular hepatic steatosis (HP:0001414)	838: Induction, Microvesicular fat
450	occurrence	autophagic cell death (GO:0048102)	4 Events 833: Occurrence, Cytoplasmic vacuolization (hepatocyte) 835: Occurrence, Ballooning degeneration (hepatocyte) 836: Occurrence, Cytoplasmic vacuolization (Bile duct cell) 837: Occurrence, Cytoplasmic vacuolization (kupffer cell)
456	increased	porphyria (MP:0005654)	369: Uroporphyria
458	decreased	regulation of intracellular pH (GO:0051453)	867: Decrease, Intracellular pH
459	increased	leukocyte mediated cytotoxicity (GO:0001909)	768: Increase, Cytotoxicity
461	increased	necrotic cell death (GO:0070265)	2 Events 868: Increase, Tissue Degeneration, Necrosis & Atrophy 1263: Necrosis
466	occurrence	renal tubular necrosis (MP:0004154)	1097: Occurrence, renal proximal tubular necrosis
471	occurrence	liver inflammation (MP:0001860)	902: Inflammation, Liver
474	decreased	epithelial cell apoptotic process (GO:1904019)	None
481	decreased	respiratory function trait (VT:0002327)	1250: Decrease, Lung function
482	occurrence	mucus secretion (GO:0070254)	None
1	increased	cell proliferation (GO:0008283)	3 Events 57: Proliferation, Cell proliferation in the absence of cytotoxicity 416: Increase proliferation, Leydig cell 1182: Increase, Cell Proliferation (Epithelial Cells)
2	increased	hyperplasia (MESH:D006965)	3 Events 142: Hyperplasia, Hyperplasia 415: Hyperplasia, Leydig cell 1192: Increased, Ductal Hyperplasia
3	increased	hepatocellular carcinoma (MESH:D006528)	334: Promotion, Hepatocelluar carcinoma
10	increased	loss of dopaminergic neurons (MP:0003244)	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway
13	decreased	ecdysis-triggering hormone activity (GO:0008255)	988: Decrease, Circulating ecdysis triggering hormone