Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 926 to 950 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
763 increased viral translation (GO:0019081) ssRNA viral genome (GO:0019024) 1847: Increased SARS-CoV-2 production
764 increased cellular response to oxidative stress (GO:0034599) reactive oxygen species (CHEBI:26523) 1869: Diminished protective oxidative stress response
765 increased response to reactive oxygen species (GO:0000302) reactive oxygen species (CHEBI:26523)
767 increased endocytosis involved in viral entry into host cell (GO:0075509) None
768 increased protease binding (GO:0002020) None
769 increased neuropilin binding (GO:0038191) None
774 increased deoxyribonucleic acid (CHEBI:16991) 1879: Bulky DNA adducts, increase
780 increased negative regulation of fibrinolysis (GO:0051918) 1866: Fibrinolysis, decreased
782 increased increased vascular permeability (MP:0003070) 1867: Bradykinin system, hyperactivated
783 increased vasodilation (GO:0042311) 1867: Bradykinin system, hyperactivated
784 increased vascular inflammation (MP:0001863) 1867: Bradykinin system, hyperactivated
797 increased oxidative phosphorylation uncoupler activity (GO:0017077) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
799 increased proton binding (GO:1901691) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
804 increased translation (GO:0006412) mucin-5AC (PR:000031343) 962: Increase, Mucin production
805 increased mucus secretion (GO:0070254) lung goblet cell (CL:1000143) 1251: Chronic, Mucus hypersecretion
806 increased NLRP3 inflammasome complex assembly (GO:0044546) NLRP3 inflammasome complex (GO:0072559) 1895: NLRP3 inflammasome activity, increased
811 increased glycosylation (GO:0070085) mucin-5AC (PR:000031343) 1910: Mucus Viscosity, Increased
812 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (human) (PR:Q9BYF1) None
813 increased regulation of peptidase activity (GO:0052547) angiotensin-converting enzyme (human) (PR:P12821) None
815 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
816 increased carboxypeptidase activity (GO:0004180) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
818 increased angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
819 increased phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) 941: Activation, EGFR
821 increased synaptic transmission, glutamatergic (GO:0035249) None
822 increased synaptic transmission, glutamatergic (GO:0035249) glutamate(1-) (CHEBI:14321) None