Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 926 to 950 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
678 decreased glutathione biosynthetic process (GO:0006750) glutathione (CHEBI:16856) 1287: Glutathione synthesis
685 decreased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 195: Inhibition, NMDARs
687 decreased glutamate secretion (GO:0014047) glutamate(1-) (CHEBI:14321) 383: Reduced, Presynaptic release of glutamate
696 decreased vascular endothelial growth factor A (PR:000017284) None
697 decreased abnormal protein level (MP:0008469) vascular endothelial growth factor A (PR:000017284) 948: reduced production, VEGF
698 decreased enzyme inhibitor activity (GO:0004857) histone deacetylase 1 (PR:000008478) 1502: Histone deacetylase inhibition
703 decreased spermatocyte (CL:0000017) 1515: Spermatocyte depletion
704 decreased testicular atrophy (MP:0003205) Testis (FMA:7210) None
705 decreased fatty acid beta-oxidation (GO:0006635) 1528: Fatty Acid Beta Oxidation, Decreased
706 decreased regulation of hormone levels (GO:0010817) thyroxine (CHEBI:30660) 280: Thyroxine (T4) in neuronal tissue, Decreased
710 decreased abnormal circulating thyroxine level (MP:0005475) thyroxine (CHEBI:30660) 281: Thyroxine (T4) in serum, Decreased
711 decreased abnormal circulating hormone level (MP:0005418) 3,3',5'-triiodothyronine (CHEBI:28774) None
712 decreased abnormal circulating hormone level (MP:0005418) 3,3',5-triiodo-L-thyronine (CHEBI:18258) None
713 decreased abnormal circulating hormone level (MP:0005418) None
716 decreased hypoxia (MP:0005039) hypoxia-inducible factor 1-alpha (PR:000008555) 1394: Induction, persistent proliferation/sustained proliferation
717 decreased hypoxia (MP:0005039) von Hippel-Lindau disease tumor suppressor (PR:000017294) 1394: Induction, persistent proliferation/sustained proliferation
718 decreased hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) von Hippel-Lindau disease tumor suppressor (PR:000017294) None
720 decreased phagocytosis (GO:0006909) macrophage (CL:0000235) 1668: Frustrated phagocytosis
726 decreased androgen biosynthetic process (GO:0006702) None
727 decreased androgen biosynthetic process (GO:0006702) 11-Keto-testosterone (CHEBI:34133) 1756: Decreased, plasma 11-ketotestosterone level
729 decreased activin receptor signaling pathway (GO:0032924) activin complex (GO:0048180) None
730 decreased activin receptor signaling pathway (GO:0032924) activin receptor complex (GO:0048179) None
731 decreased fin regeneration (GO:0031101) blastemal cell (CL:0000354) 1761: Inhibition, Fin regeneration
734 decreased cholesterol transport (GO:0030301) cholesterol (CHEBI:16113) 807: Decreased, cholesterol
735 decreased cholesterol transport (GO:0030301) cholesteryl ester (CHEBI:17002) 807: Decreased, cholesterol