Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 951 to 975 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
380 decreased pyruvate dehydrogenase activity (GO:0004738) Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (rat) (PR:Q63065) 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
379 increased pyruvate dehydrogenase activity (GO:0004738) pyruvate dehydrogenase [ubiquinone] (PR:000023575) 726: Increased, Induction of pyruvate dehydrogenase (PDH)
261 increased signaling (GO:0023052) RAC-beta serine/threonine-protein kinase (PR:000003912) 484: Activation, AKT2
764 increased cellular response to oxidative stress (GO:0034599) reactive oxygen species (CHEBI:26523) 1869: Diminished protective oxidative stress response
765 increased response to reactive oxygen species (GO:0000302) reactive oxygen species (CHEBI:26523)
766 occurrence regulation of response to reactive oxygen species (GO:1901031) reactive oxygen species (CHEBI:26523) 1634: Increase, Oxidative DNA damage
120 increased reactive oxygen species biosynthetic process (GO:1903409) reactive oxygen species (CHEBI:26523) 1115: Increase, Reactive oxygen species
579 increased reactive oxygen species (CHEBI:26523) None
667 increased biosynthetic process (GO:0009058) reactive oxygen species (CHEBI:26523) None
443 occurrence autophagic cell death (GO:0048102) renal tubule (UBERON:0009773) 818: Occurrence, Cytoplasmic vacuolization (Renal tubule)
444 occurrence Dilatation (MESH:D004106) renal tubule (UBERON:0009773) 823: Occurrence, Cystic dilatation (renal tubule)
1141 increased abnormal reproductive system development (MP:0003936) reproductive organ (UBERON:0003133) 2415: Precocious puberty
143 abnormal developmental process (GO:0032502) reproductive organ (UBERON:0003133) 364: Impaired development of, Reproductive organs
620 increased Respiratory Hypersensitivity (MESH:D012130) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
625 increased inflammatory response (GO:0006954) respiratory system (UBERON:0001004) 1226: Increased Respiratory irritability and Chronic Cough,
785 morphological change retina layer formation (GO:0010842) retina (UBERON:0000966) 1877: Altered, retinal layer structure
1059 decreased retinoic acid biosynthetic process (GO:0002138) retinal dehydrogenase 1 (PR:000003920) 1880: Decreased, ALDH1A (RALDH) enzyme activity
786 decreased pattern recognition receptor signaling pathway (GO:0002221) RNA viral genome (GO:0019022) None
880 occurrence cellular response to exogenous dsRNA (GO:0071360) RNA viral genome (GO:0019022) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
891 decreased secondary palatal shelf (UBERON:0005619) None
893 decreased abnormal palatal shelf fusion at midline (MP:0009887) secondary palate (UBERON:0001716) None
1096 increased palatal shelves fail to meet at midline (MP:0009888) secondary palate (UBERON:0001716) 2041: Decrease, facial prominence outgrowth
949 occurrence transcription, RNA-templated (GO:0001172) segmented viral genome (GO:0019017) 2192: Influenza A Virus production increased
84 occurrence protein binding (GO:0005515) Selenium-Binding Proteins (MESH:D051137) 261: Binding, SH-/selen-proteins
1077 increased increased serotonin level (MP:0010069) serotonin (CHEBI:28790) 1320: Increased, extracellular serotonin