Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 951 to 975 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
730 decreased activin receptor signaling pathway (GO:0032924) activin receptor complex (GO:0048179) None
851 disrupted action potential (GO:0001508) 1983: Disruption, action potential generation
326 decreased action potential (GO:0001508) 585: Decreased, Sodium conductance 1
360 abnormal action potential (GO:0001508) 698: Altered, Action Potential
594 increased acidosis (MP:0003031) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
75 decreased acetylcholinesterase activity (GO:0003990) acetylcholinesterase (PR:000003626) 12: Acetylcholinesterase (AchE) Inhibition
301 increased acetylcholine receptor activity (GO:0015464) Nicotinic acetylcholine receptor (FMA:61796) 559: Activation, Nicotinic acetylcholine receptor
322 increased acetylcholine receptor activator activity (GO:0030549) Nicotinic acetylcholine receptor (FMA:61796) 663: Desensitization, Nicotinic acetylcholine receptor
248 increased acetyl-CoA carboxylase activity (GO:0003989) acetyl-CoA carboxylase 1 (PR:000003596) 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
963 increased Abnormality of the testis (HP:0000035) Testis (FMA:7210) 2206: Increased, histomorphological alteration of testis
564 increased abnormal tumor latency (MP:0010307) 1080: Increased, latency period
733 abnormal Abnormal spermatogenesis (HP:0008669) Mature sperm cell (FMA:67338) 1758: Impaired, Spermatogenesis
340 decreased abnormal sheltering behavior (MP:0014039) 629: Decreased, sheltering
1141 increased abnormal reproductive system development (MP:0003936) reproductive organ (UBERON:0003133) 2415: Precocious puberty
697 decreased abnormal protein level (MP:0008469) vascular endothelial growth factor A (PR:000017284) 948: reduced production, VEGF
893 decreased abnormal palatal shelf fusion at midline (MP:0009887) secondary palate (UBERON:0001716) None
295 delayed abnormal ovulation (MP:0001928) 532: Delayed, Ovulation
559 disrupted abnormal ovulation (MP:0001928) 1074: interruption, Ovulation
237 abnormal abnormal neuron morphology (MP:0002882) 851: Decrease of GABAergic interneurons
270 abnormal abnormal nervous system physiology (MP:0003633) 192: Altered, Neurophysiology
315 decreased abnormal maternal nurturing (MP:0001386) 565: Reduced, Brood care
1099 increased abnormal long term potentiation (MP:0002207) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1071 disrupted abnormal lipid metabolism (MP:0013245) 2300: Disruption, Glucolipid metabolism
28 abnormal abnormal lipid homeostasis (MP:0002118) 862: Not Increased, Circulating Ketone Bodies
911 decreased abnormal glutathione level (MP:0012603) glutathione (CHEBI:16856) 130: Depletion, GSH