Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 51 to 75 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
491 abnormal antioxidant activity (GO:0016209) glutathione (CHEBI:16856) 926: Oxidation, Glutathione (To be considered with MIE)
146 abnormal gene expression (GO:0010467) hemoglobin subunit alpha (human) (PR:P69905) 21: Altered regulation, Alpha hemoglobin
679 abnormal cholesterol (CHEBI:16113) 1289: Perturbation of cholesterol
968 abnormal animal organ formation (GO:0048645) urethra (UBERON:0000057) 2213: Impaired, urethral tube closure
237 abnormal abnormal neuron morphology (MP:0002882) 851: Decrease of GABAergic interneurons
348 abnormal fertility (MESH:D005298) 673: Reduced, Spawning behavior
601 abnormal post-translational protein modification (GO:0043687) osteocalcin (PR:000030444) 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
979 abnormal animal organ development (GO:0048513) gonad (UBERON:0000991) 1615: Impaired inguinoscrotal testicular descent phase
222 abnormal capillary plexus (UBERON:0035753) 298: Insufficiency, Vascular
286 abnormal cytoskeleton organization (GO:0007010) Leydig cell (CL:0000178) 649: Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
29 abnormal ketone body (CHEBI:73693) 862: Not Increased, Circulating Ketone Bodies
321 abnormal calmodulin binding (GO:0005516) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
302 abnormal foraging behavior (GO:0060756) 560: Abnormal, Foraging activity and behavior
141 abnormal reproductive behavior (GO:0019098) 363: Altered, Reproductive behaviour
42 abnormal regulation of gene expression (GO:0010468) hippocampal formation (UBERON:0002421) 756: Hippocampal gene expression, Altered
661 abnormal DNA topoisomerase II activity (GO:0061505) 1252: Binding to (interferes with) topoisomerase II enzyme
973 abnormal animal organ development (GO:0048513) 1616: Malformation, cryptorchidism - maldescended testis
377 abnormal regulation of gene expression (GO:0010468) 1214: Altered gene expression specific to CAR activation, Hepatocytes
550 abnormal lipid metabolic process (GO:0006629) 1060: Alteration, lipid metabolism
708 abnormal chemical synaptic transmission (GO:0007268) synapse (GO:0045202) 758: Hippocampal Physiology, Altered
652 abnormal translation (GO:0006412) protein (PR:000000001) 1240: Altered, Protein Production
660 abnormal Food Chain (MESH:D020387) 1210: Alteration, Food-web structures
825 abnormal otic vesicle formation (GO:0030916) 1930: altered, inner ear development
279 abnormal fetal proteins (MESH:D005326) 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
360 abnormal action potential (GO:0001508) 698: Altered, Action Potential