Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 51 to 75 of 1146 KECs

ID	Action	Process	Associated Key Events (KEs)


215	decreased	learning or memory (GO:0007611)	402: Cognitive function, decreased
81	increased	hyperactivity (MP:0001399)	3 Events 39: Increased Cholinergic Signaling 602: Increased, Ataxia, paralysis, or hyperactivity 764: N/A, Ataxia, paralysis, or hyperactivity
216	decreased	cognition (GO:0050890)	402: Cognitive function, decreased
233	increased	hemorrhage (MP:0001914)	2 Events 421: Increased, glomerular rupture and renal hemorrhaging 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
105	morphological change	abnormal cardiovascular system physiology (MP:0001544)	317: Altered, Cardiovascular development/function
3	increased	hepatocellular carcinoma (MESH:D006528)	334: Promotion, Hepatocelluar carcinoma
2	increased	hyperplasia (MESH:D006965)	3 Events 142: Hyperplasia, Hyperplasia 415: Hyperplasia, Leydig cell 1192: Increased, Ductal Hyperplasia
109	decreased	egg quantity (VT:1000294)	2 Events 78: Reduction, Cumulative fecundity and spawning 972: Decreased fertility, Reduced number of oocytes ovulated
234	increased	Nephropathy (HP:0000112)	422: Increased, nephropathy
87	occurrence	oxidative stress (MP:0003674)	None
36	disrupted	ovulation cycle (GO:0042698)	None
35	decreased	fertility (MESH:D005298)	406: decreased, Fertility
267	decreased	sperm quantity (VT:0002673)	520: Decreased sperm quantity or quality in the adult, Decreased fertility
266	increased	apoptotic process (GO:0006915)	3 Events 496: Increased apoptosis, decreased fetal/adult Leydig Cells 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells 1262: Apoptosis
223	morphological change	anatomical structure morphogenesis (GO:0009653)	1001: Increased, Developmental Defects
31	decreased	weight loss (MP:0001263)	None
201	increased	cell activation (GO:0001775)	3 Events 398: Activation, Dendritic Cells 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 981: Reduction, NFAT/AP-1 complex formation
1	increased	cell proliferation (GO:0008283)	3 Events 57: Proliferation, Cell proliferation in the absence of cytotoxicity 416: Increase proliferation, Leydig cell 1182: Increase, Cell Proliferation (Epithelial Cells)
28	abnormal	abnormal lipid homeostasis (MP:0002118)	862: Not Increased, Circulating Ketone Bodies
27	decreased	ketosis (MESH:D007662)	2 Events 861: Decreased, Ketogenesis (production of ketone bodies) 477: Decreased, Ketogenesis
149	increased	hemoglobin binding (GO:0030492)	118: Formation, Formation of hemoglobin adducts
83	decreased	population growth rate (PCO:0000008)	4 Events 442: Decreased, Population trajectory 361: Decline, Population 679: Decline, Population trajectory 1136: Impaired recruitment , Population trajectory
152	increased	liver vascular congestion (MP:0010019)	246: Increase, RBC congestion in liver
88	increased	neuron death in response to oxidative stress (GO:0036475)	191: Neuronal dysfunction
82	increased	paralysis (MP:0000753)	5 Events 39: Increased Cholinergic Signaling 602: Increased, Ataxia, paralysis, or hyperactivity 764: N/A, Ataxia, paralysis, or hyperactivity 1014: Induction, Somatic muscle paralysis 1019: Induction, pharyngeal muscle paralysis