Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 51 to 75 of 1146 KECs

ID	Action	Object	Associated Key Events (KEs)


297	abnormal	fertilization envelope (GO:0060387)	534: Altered, Formation of cortical envelope
346	decreased	prostaglandin F2alpha (CHEBI:15553)	2 Events 671: Reduced, Prostaglandin F2alpha concentration, plasma 1104: Decreased, Prostaglandin F2alpha concentration, plasma
6	functional change	mitochondrion (GO:0005739)	2 Events 177: Increase, Mitochondrial dysfunction 2363: Elevated mitochondrial ROS and dysfunction
232	functional change	glomerular basement membrane (UBERON:0005777)	421: Increased, glomerular rupture and renal hemorrhaging
117	increased	calcium ion (CHEBI:39124)	50: Increase, Ca++ (intracellular)
134	decreased	eggshell (UBERON:0005079)	106: Reduction, Eggshell thickness
132	decreased	prostaglandin E2 (CHEBI:15551)	2 Events 243: Reduction, Prostaglandin E2 concentration 687: Reduced, Prostaglandin E2 concentration, hypothalamus
29	abnormal	ketone body (CHEBI:73693)	862: Not Increased, Circulating Ketone Bodies
352	increased	3',5'-cyclic AMP(1-) (CHEBI:58165)	693: Increased, cyclic adenosine monophosphate
94	decreased	testosterone (CHEBI:17347)	2 Events 446: Reduction, fetal/adult testosterone 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
457	increased	uroporphyrinogen (CHEBI:27258)	844: Oxidation, Uroporphyrinogen
176	increased	triglyceride (CHEBI:17855)	291: Accumulation, Triglyceride
404	increased	papilloma (MESH:D010212)	779: Increase, Papillomas/carcinomas (squamous cells)
33	decreased	17beta-estradiol (CHEBI:16469)	2 Events 219: Reduction, Plasma 17beta-estradiol concentrations 1056: Decrease, E2 blood concentrations at hypothalamus
369	increased	major urinary protein (rat) (PR:P02761)	708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
77	increased	atrioventricular block (MESH:D054537)	444: Increased, Atrioventricular block and bradycardia
95	morphological change	male reproductive organ (UBERON:0003135)	348: Malformation, Male reproductive tract
440	increased	creatinine (CHEBI:16737)	813: Increased, Serum creatinine
431	morphological change	male reproductive system (UBERON:0000079)	809: malformed, Male reproductive tract
126	increased	bile (UBERON:0001970)	214: Bile accumulation, Pathological condition
180	abnormal	plasma membrane (GO:0005886)	169: Disruption, Membrane integrity
151	increased	erythrocyte (CL:0000232)	2 Events 246: Increase, RBC congestion in liver 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
429	decreased	cholesterol (CHEBI:16113)	None
353	decreased	Gonadotropin Releasing Hormone (MESH:D007987)	689: Reduced, Gonadotropin releasing hormone, hypothalamus
153	increased	hemosiderosis (MESH:D006486)	161: Increase, Liver and splenic hemosiderosis