Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 51 to 75 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
193 increased transforming growth factor beta1 production (GO:0032905) TGF-beta 1 (PR:000000182) 276: Up Regulation, TGFbeta1 expression
475 occurrence transdifferentiation (GO:0060290) ciliated epithelial cell (CL:0000067) 919: Occurrence, Transdifferentiation of ciliated epithelial cells
949 occurrence transcription, RNA-templated (GO:0001172) segmented viral genome (GO:0019017) 2192: Influenza A Virus production increased
789 decreased transcription, DNA-templated (GO:0006351) None
23 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 2 (PR:000011048) 1000: stabilization, PPAR alpha co-repressor
24 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 1 (PR:000011047) 1000: stabilization, PPAR alpha co-repressor
442 occurrence toxicity (MESH:Q000633) kidney (UBERON:0002113) 814: Occurrence, Kidney toxicity
869 increased toll-like receptor signaling pathway (GO:0002224) Toll-like receptor (PR:000001096) 1495: Substance interaction with the lung resident cell membrane components
935 occurrence toll-like receptor 7 signaling pathway (GO:0034154) viral genome (GO:0019015) None
937 decreased toll-like receptor 7 signaling pathway (GO:0034154) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
870 increased toll-like receptor 4 signaling pathway (GO:0034142) Toll-like receptor 4 (PR:000001155) 1495: Substance interaction with the lung resident cell membrane components
934 occurrence toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
936 decreased toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
938 decreased toll-like receptor 3 signaling pathway (GO:0034138) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
1014 decreased thyroid hormone transport (GO:0070327) monocarboxylate transporter 8 (PR:000014950) 2258: Inhibition, monocarboxylate transporter 8 (MCT8)
214 decreased thyroid hormone generation (GO:0006590) thyroid hormone (CHEBI:60311) 277: Thyroid hormone synthesis, Decreased
307 abnormal thermoregulation behavior (NBO:0000051) 568: impaired, Hive thermoregulation
1028 increased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347) 2272: Testosterone levels, increased
93 decreased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347)
274 increased Testicular dysgenesis (HP:0008715)
704 decreased testicular atrophy (MP:0003205) Testis (FMA:7210) None
723 increased Testicular atrophy (HP:0000029) Testis (FMA:7210) 1506: Testicular atrophy
1054 occurrence T cell migration (GO:0072678) T cell (CL:0000084) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1042 increased T cell migration (GO:0072678) T cell (CL:0000084) None
1041 increased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) None