Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 976 to 1000 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
654 increased second-messenger-mediated signaling (GO:0019932) 1242: Increased, Second Messenger Production
896 decreased second-messenger-mediated signaling (GO:0019932) None
907 decreased second-messenger-mediated signaling (GO:0019932) sonic hedgehog protein (PR:000014841) 2043: Decrease, Sonic Hedgehog second messenger production
738 occurrence secondary generalized seizure (NBO:0000703) brain (UBERON:0000955) 1788: Status epilepticus
532 increased secretion (GO:0046903) eukaryotic protein (PR:000036194) 1032: Increased, secretion of local growth factors
56 decreased secretion (GO:0046903) brain-derived neurotrophic factor (PR:000004716) 381: Reduced levels of BDNF
238 decreased secretion (GO:0046903) very-low-density lipoprotein (CHEBI:39027) 450: Decrease, Very low-density lipoprotein export capacity
296 decreased secretion (GO:0046903) cortical granule (GO:0060473) 533: Decreased, Cortical granule release/distribution upon fertilization
480 increased secretion (GO:0046903) mucin-5AC (PR:000031343) None
53 occurrence seizures (NBO:0000025) 613: Occurrence, Epileptic seizure
525 decreased sensory perception of sound (GO:0007605) 1008: Reduced, Hearing
1075 increased serotonin receptor activity (GO:0099589) Surface of brain (FMA:86594) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1078 increased serotonin receptor signaling pathway (GO:0007210) Serotonin receptor (FMA:67372) None
1080 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 1A (PR:000001161) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1081 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 2C (PR:000001168) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
338 decreased serotonin secretion (GO:0001820) sodium-dependent serotonin transporter (PR:000015189) 626: Increased, serotonin (5-HT)
341 decreased serotonin uptake (GO:0051610) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
231 abnormal sex ratio (MESH:D012744) 417: skewed, sex ratio
939 decreased sexual reproduction (GO:0019953) 2147: Decreased, Viable Offspring
923 decreased signaling (GO:0023052) neurotransmitter (CHEBI:25512) 2151: Disruption, neurotransmitter release
37 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 2 (PR:000011397)
38 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 715: Activation, Constitutive androstane receptor
164 increased signaling (GO:0023052) 5-hydroxytryptamine receptor 2C (PR:000001168) 9: Activation, 5HT2c
166 increased signaling (GO:0023052) oxysterols receptor LXR-beta (PR:000011394) 167: Activation, LXR
167 increased signaling (GO:0023052) oxysterols receptor LXR-alpha (PR:000011395)