Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 976 to 1000 of 1147 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


273	increased	abnormal fetal Leydig cell differentiation (MP:0013603)		3 Events 657: Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells 660: decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells 540: Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
981	morphological change	abnormal excitatory postsynaptic current amplitude (MP:0011267)	dendritic spine membrane (GO:0032591)	388: Overactivation, NMDARs
864	increased	abnormal DNA repair (MP:0008058)	DNA repair complex (GO:1990391)	1669: Increased, DNA damage and mutation
710	decreased	abnormal circulating thyroxine level (MP:0005475)	thyroxine (CHEBI:30660)	281: Thyroxine (T4) in serum, Decreased
711	decreased	abnormal circulating hormone level (MP:0005418)	3,3',5'-triiodothyronine (CHEBI:28774)	None
712	decreased	abnormal circulating hormone level (MP:0005418)	3,3',5-triiodo-L-thyronine (CHEBI:18258)	None
713	decreased	abnormal circulating hormone level (MP:0005418)		None
801	decreased	Abnormal ciliary motility (HP:0012262)	motile cilium (GO:0031514)	None
802	occurrence	Abnormal ciliary motility (HP:0012262)	motile cilium (GO:0031514)	1908: Cilia Beat Frequency, Decreased
299	increased	abnormal chromosome number (MP:0004023)		3 Events 536: Altered, Chromosome number (polyploid) zygote 723: Altered, Chromosome number 728: Increase, Aneuploid offspring
105	morphological change	abnormal cardiovascular system physiology (MP:0001544)		317: Altered, Cardiovascular development/function
1003	occurrence	abnormal bone remodeling (MP:0002998)		2090: Increase, Bone Remodeling
912	occurrence	abnormal blood coagulation (MP:0002551)	blood (UBERON:0000178)	1845: Coagulation
441	increased	abnormal amino acid level (MP:0005332)		813: Increased, Serum creatinine
276	increased	abnormal adult Leydig cell differentiation (MP:0013604)		541: Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
624	increased	abnormal acute inflammation (MP:0002498)		1225: Immune system inflammation
406	decreased	4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868)	4-hydroxyphenylpyruvate dioxygenase (rat) (PR:P32755)	766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
186	decreased	3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857)	3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)	2 Events 8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
6	functional change		mitochondrion (GO:0005739)	2 Events 177: Increase, Mitochondrial dysfunction 2363: Elevated mitochondrial ROS and dysfunction
11	occurrence		Parkinsonian disorders (MESH:D020734)	896: Parkinsonian motor deficits
29	abnormal		ketone body (CHEBI:73693)	862: Not Increased, Circulating Ketone Bodies
33	decreased		17beta-estradiol (CHEBI:16469)	2 Events 219: Reduction, Plasma 17beta-estradiol concentrations 1056: Decrease, E2 blood concentrations at hypothalamus
41	decreased		thyroxine (CHEBI:30660)	3 Events 771: Decrease, Serum thyroid hormone (T4/T3) 1022: Decreased, serum T4/T3 1093: Decreased, Thyroxine (T4) in tissues
43	morphological change		hippocampal formation (UBERON:0002421)	None
68	decreased		lymphocyte (CL:0000542)	168: Decreased, Lymphocytes