Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1001 to 1025 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
905 increased endocrine signaling (GO:0038002) estrone (CHEBI:17263) 2092: Promotion, Ovarian Cancer
910 increased glutathione binding (GO:0043295) glutathione conjugate (CHEBI:24335) 2131: Conjugation, GSH
915 increased blood coagulation, fibrin clot formation (GO:0072378) Fibrin (CHEBI:5054) 1846: Thrombosis and Disseminated Intravascular Coagulation
919 increased respiratory electron transport chain (GO:0022904) superoxide (CHEBI:18421) 2120: Superoxide generation, increased
920 increased Insulin resistance (HP:0000855) 2119: Increase, Insulin resistance
921 increased kinase activity (GO:0016301) astrocyte (CL:0000127) 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
922 increased calcium amount (VT:0010499) calcium(2+) (CHEBI:29108) 1339: Increase, intracellular calcium
941 increased acute-phase response (GO:0006953) None
942 increased Atherosclerosis (HP:0002621) 1443: Atherosclerosis
943 increased acute-phase response (GO:0006953) Acute phase proteins (N/A)
958 increased Breast carcinoma (HP:0003002) VEGF-A complex (GO:1990150) 1376: Increase, angiogenesis
959 increased Breast carcinoma (HP:0003002) BRCA1-A complex (GO:0070531) 1971: Increased, tumor growth
960 increased Hepatic steatosis (HP:0001397) 459: Increase, Liver steatosis
961 increased hepatocyte (CL:0000182) None
962 increased lipid oxidation (GO:0034440) polyunsaturated fatty acid (CHEBI:26208) 1445: Increase, Lipid peroxidation
963 increased Abnormality of the testis (HP:0000035) Testis (FMA:7210) 2206: Increased, histomorphological alteration of testis
969 increased specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
970 increased increased apoptosis (MP:0006042) 1513: General Apoptosis
971 increased gene expression (GO:0010467) lipid (CHEBI:18059) None
989 increased blood viscosity trait (VT:3000004) blood (UBERON:0000178) 2238: Increased, Blood viscosity
992 increased estradiol (CHEBI:23965) 2251: Estradiol availability, increased
993 increased energy deposition event (RBO:00015021) 1686: Deposition of Energy
994 increased DNA Strand Break (NCI:C25830) Deoxyribonucleic acid (FMA:74412) 1635: Increase, DNA strand breaks
996 increased demyelination (MP:0000921)
997 increased neuron death (GO:0070997) 2098: Increase, Abnormal Neural Remodeling