Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1001 to 1025 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
171 increased signaling (GO:0023052) carbohydrate-responsive element-binding protein (PR:000010460) 66: Activation, ChREBP
205 increased signaling (GO:0023052) aryl hydrocarbon receptor (PR:000003858) 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes
507 decreased signaling (GO:0023052) aromatase (PR:000006100) 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
592 decreased signaling (GO:0023052) androgen receptor (PR:000004191) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
605 decreased signaling (GO:0023052) pendrin (PR:000015039) 1155: Inhibition, Pendrin
607 increased signaling (GO:0023052) protein (PR:000000001) 1157: Activation, Hepatic nuclear receptor(s)
614 increased signaling (GO:0023052) transient receptor potential cation channel TRPV1 (PR:000001065)
635 decreased signaling (GO:0023052) sodium channel protein type 1 subunit alpha (PR:000002095) 584: Inhibition, sodium channel
638 increased signaling (GO:0023052) estrogen receptor (PR:000007204) None
643 increased signaling (GO:0023052) 1191: Increased, Non-genomic signaling
655 increased signaling (GO:0023052) juvenile hormone (CHEBI:24943) 1205: Activation, Juvenile hormone receptor
666 increased signaling (GO:0023052) NADPH Oxidase (MESH:D019255) 1174: Activation, NADPH Oxidase
668 increased signaling (GO:0023052) map kinase p38 (PR:000003106) 1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK
669 increased signaling (GO:0023052) hypoxia-inducible factor 1 (Caenorhabditis elegans) (PR:G5EGD2) 1280: Activation, HIF-1
671 increased signaling (GO:0023052) Janus kinase (PR:000025748) 1282: Activation, JAK/STAT pathway
672 increased signaling (GO:0023052) signal transducer and transcription activator STAT (PR:000001933) 1282: Activation, JAK/STAT pathway
673 increased signaling (GO:0023052) TGF-beta (PR:000000046) 1283: Activation, TGF-beta pathway
681 increased signaling (GO:0023052) JNK Mitogen-Activated Protein Kinases (MESH:D048031) 1292: Activation, JNK
682 increased signaling (GO:0023052) forkhead box protein O (Caenorhabditis elegans) (PR:O16850) 1293: Activation, FOXO
683 abnormal signaling (GO:0023052) Wnt signalosome (GO:1990909) 1294: Inhibition, Wnt pathway
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1I3
245 increased signaling (GO:0023052) sterol regulatory element-binding protein 1 (PR:000015611) 457: Activation, SREBF1
249 decreased signaling (GO:0023052) hepatocyte nuclear factor 4-alpha (PR:000008654) 461: Suppression, HNF4alpha
250 decreased signaling (GO:0023052) hepatocyte nuclear factor 3-beta (PR:000007603) 471: Inhibition, FoxA2
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2