Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1026 to 1050 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
998 increased cell surface receptor signaling pathway (GO:0007166)
1005 increased osteoclast differentiation (GO:0030316) 2089: Altered Bone Cell Homeostasis
1006 increased cell death (GO:0008219) bone cell (CL:0001035) 1825: Increase, Cell death
1009 increased endothelial cell apoptotic process (GO:0072577) 2068: Increase, Endothelial Dysfunction
1010 increased protein modification process (GO:0036211) 2081: Increased Modified Proteins
1011 increased chromosome (GO:0005694) None
1019 increased Stress, Physiological (MESH:D013312) heart (UBERON:0000948) 2239: Increased, Cardiac stress
1021 increased lysophosphatidylcholine (CHEBI:60479) 2263: Lysolecithin, increased
1022 increased cell death (GO:0008219) oligodendrocyte (CL:0000128) 2265: Oligodendrocyte death, increased
1023 increased CNS demyelination (HP:0007305) 2266: Demyelination, increased
1025 increased increased circulating total protein level (MP:0005568) None
1026 increased cholesterol biosynthetic process (GO:0006695) 2270: Increased, cholesterol synthesis enzymes
1027 increased increased circulating LDL cholesterol level (MP:0000182) blood plasma (UBERON:0001969) None
1028 increased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347) 2272: Testosterone levels, increased
43 morphological change hippocampal formation (UBERON:0002421) None
95 morphological change male reproductive organ (UBERON:0003135) 348: Malformation, Male reproductive tract
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
105 morphological change abnormal cardiovascular system physiology (MP:0001544) 317: Altered, Cardiovascular development/function
223 morphological change anatomical structure morphogenesis (GO:0009653) 1001: Increased, Developmental Defects
268 morphological change sperm (CL:0000019) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
431 morphological change male reproductive system (UBERON:0000079) 809: malformed, Male reproductive tract
556 morphological change Metaplasia (MESH:D008679) None
646 morphological change extracellular matrix (GO:0031012) 1195: modulation, Extracellular Matrix Composition
707 morphological change brain development (GO:0007420) hippocampal formation (UBERON:0002421) 757: Hippocampal anatomy, Altered
785 morphological change retina layer formation (GO:0010842) retina (UBERON:0000966) 1877: Altered, retinal layer structure