Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1026 to 1050 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
255 increased signaling (GO:0023052) bile acid receptor (PR:000011396) 479: Activation, NR1H4
256 increased signaling (GO:0023052) nuclear receptor subfamily 0 group B member 2 (PR:000011391) 480: Activation, SHP
258 increased signaling (GO:0023052) microsomal triglyceride transfer protein large subunit MTTP (PR:000003392) 879: Activation, MTTP
261 increased signaling (GO:0023052) RAC-beta serine/threonine-protein kinase (PR:000003912) 484: Activation, AKT2
292 decreased signaling (GO:0023052) proto-oncogene c-Fos (mouse) (PR:P01101) 529: Decreased, GnRH cfos activity
305 abnormal signaling (GO:0023052) calmodulin (PR:000004978) 1243: Altered, Ca2+-calmodulin activated signal transduction
358 decreased signaling (GO:0023052) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte
427 abnormal signaling (GO:0023052) hypoxia-inducible factor 1-alpha (PR:000008555) 801: modulation, Unknown
435 decreased signaling (GO:0023052) alpha-2A adrenergic receptor (PR:000001186) 849: Inhibition, Antgonism of NE receptor
464 decreased signaling (GO:0023052) solute carrier family 22 member 6 (PR:000014993) 877: Inhibition, organic anion transporter 1 (OAT1)
986 functional change sodium channel activity (GO:0005272) voltage-gated sodium channel complex (GO:0001518) 1977: Disruption of sodium channel gating kinetics
325 decreased sodium channel inhibitor activity (GO:0019871) sodium channel protein type 1 subunit alpha (PR:000002095)
1016 decreased sodium ion import (GO:0097369) gill (UBERON:0002535) 2236: Decreased, Sodium uptake in gills
235 decreased sodium:iodide symporter activity (GO:0008507) sodium/iodide cotransporter (PR:000015171) 424: Inhibition, Na+/I- symporter (NIS)
987 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) None
1013 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) sodium:potassium-exchanging ATPase complex (GO:0005890) 1562: Decreased Na/K ATPase activity
969 increased specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
972 abnormal specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
298 abnormal sperm entry (GO:0035037) 535: Abnormal, Sperm penetration (polyspermy)
267 decreased sperm quantity (VT:0002673) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
374 decreased spindle organization (GO:0007051) spindle (GO:0005819) 721: Disorganization, Meiotic Spindle
172 increased SREBP signaling pathway (GO:0032933) sterol regulatory element-binding protein 1 (PR:000015611)
283 decreased steroid biosynthetic process (GO:0006694) 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
355 decreased steroid hormone receptor activity (GO:0003707) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte
409 increased stomach epithelial hyperplasia (MP:0005493) epithelial cell (CL:0000066) 782: Increase, Hyperplasia (forestomach epithelial cells)