Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1026 to 1050 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
982 decreased impaired synaptic plasticity (MP:0001900) actin cytoskeleton of dendritic spine (GO:0098938) None
983 decreased postsynaptic actin cytoskeleton organization (GO:0098974) drebrin (PR:000006296) 2078: Loss of drebrin
987 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) None
988 decreased import into cell (GO:0098657) sodium atom (CHEBI:26708) None
995 decreased neurogenesis (GO:0022008) 2098: Increase, Abnormal Neural Remodeling
1001 decreased bone mineralization (GO:0030282) 2090: Increase, Bone Remodeling
1004 decreased osteoblast differentiation (GO:0001649) 2089: Altered Bone Cell Homeostasis
1012 decreased sulfotransferase activity (GO:0008146) estrogen sulfotransferase (PR:000032783) 2155: Inhibition of Sulfotransferase E1 (SULT1E1)
1013 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) sodium:potassium-exchanging ATPase complex (GO:0005890) 1562: Decreased Na/K ATPase activity
1014 decreased thyroid hormone transport (GO:0070327) monocarboxylate transporter 8 (PR:000014950) 2258: Inhibition, monocarboxylate transporter 8 (MCT8)
1015 decreased regulation of body fluid levels (GO:0050878) blood plasma (UBERON:0001969) None
1016 decreased sodium ion import (GO:0097369) gill (UBERON:0002535) 2236: Decreased, Sodium uptake in gills
1017 decreased decreased circulating sodium level (MP:0005634) blood plasma (UBERON:0001969) 2237: Decreased, Plasma sodium concentrations
1018 decreased blood circulation (GO:0008015) blood plasma (UBERON:0001969) 2261: Decreased, blood plasma volume
1020 decreased neuropathy target esterase (PR:000012946) 2262: Neuropathy target esterase, inhibited
1024 decreased decreased circulating total protein level (MP:0005567) None
1045 decreased insulin-induced gene 1 protein (PR:000009056) None
1047 decreased decreased circulating total protein level (MP:0005567) insulin-induced gene 1 protein (PR:000009056) 2268: Decreased, insulin-induced gene 1 (INSIG1) protein activity
1059 decreased retinoic acid biosynthetic process (GO:0002138) retinal dehydrogenase 1 (PR:000003920) 1880: Decreased, ALDH1A (RALDH) enzyme activity
1060 decreased retinoic acid biosynthetic process (GO:0002138) all-trans-retinoic acid (CHEBI:15367) 1881: Decreased, all-trans retinoic acid (atRA) concentration
1061 decreased ovarian follicle development (GO:0001541) ovarian follicle (UBERON:0001305) 1883: Decreased, size of the ovarian reserve
1064 decreased fertilization (GO:0009566) fertility (MESH:D005298) 406: decreased, Fertility
1065 decreased ovulation (GO:0030728) Ovum (FMA:67343) 1695: Impaired ovulation
1086 decreased cytochrome-c oxidase activity (GO:0004129) mitochondrion (GO:0005739) 1840: Inhibition, cytochrome oxidase
1087 decreased Premature ovarian failure (HP:0008209) ovarian follicle (UBERON:0001305) 2305: Premature ovarian Insufficiency